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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heart failure developed after myocardial infarction does not affect gut microbiota composition in the rat

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Author(s):
Lataro, Renata M. [1] ; Imori, Priscilla F. M. [2] ; Santos, Emerson S. [2] ; Silva, V, Luiz Eduardo ; Duarte, Rubens T. D. [3] ; Silva, Carlos A. A. [4] ; Falcao, Juliana P. [2] ; Paton, Julian F. R. [5] ; Salgado, Hello C. [4]
Total Authors: 9
Affiliation:
[1] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Physiol Sci, Florianopolis, SC - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Microbiol Immunol & Parasitol, Florianopolis, SC - Brazil
[4] Silva, Luiz Eduardo, V, Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Av Bandcirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[5] Univ Auckland, Fac Med & Hlth Sci, Dept Physiol, Auckland - New Zealand
Total Affiliations: 5
Document type: Journal article
Source: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY; v. 317, n. 3, p. G342-G348, SEP 2019.
Web of Science Citations: 0
Abstract

There is a body of evidence that supports the notion that gut dysbiosis plays a role in the pathogenesis of cardiovascular diseases. Decreased cardiac function can reduce intestinal perfusion. resulting in morphological alterations, which may contribute to changes in the gut microbiota composition in patients with heart failure (HF). In this regard. a germane question is whether changes in gut microbiota composition are a cause or consequence of the cardiovascular disturbance. We tested the hypothesis that the development of HF, after myocardial infarction, would cause gut dysbiosis. Fecal samples were collected before and 6 wk after myocardial infarction or sham surgery. Gut microbiota were characterized by sequencing the bacterial 16S ribosomal DNA. The composition of bacterial communities in the fecal samples was evaluated by calculating three major ecological parameters: 1) the Chao 1 richness, 2) the Pielou evenness, and 3) the Shannon index. None of these indices was changed in either sham or HF rats. The Firmicutes/Bacteroidetes ratio was not altered in HF rats. The number of species in each phylum was also not different between sham and HF rats. beta-Diversity analysis showed that the composition of gut microbiota was not changed with the development of HF. Bacterial genera were grouped according to their major metabolic end-products (acetate, butyrate, and lactate), but no differences were observed in HF rats. Therefore, we conclude that HF induced by myocardial infarction does not affect gut microbiota composition, at least in rats, indicating that the dysbiosis observed in patients with HF may precede cardiovascular disturbance. NEW \& NOTEWORTHY Our study demonstrated that, following myocardial infarction in rats, heart failure (HF) development did not affect the intestinal microbiota despite distinct differences reported in the gut microbiota of humans with HF. Our finding is consistent with the notion that dysbiosis observed in patients with HF may precede cardiovascular dysfunction and therefore offers potential for early diagnosis and treatment. (AU)

FAPESP's process: 13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition
Grantee:Helio Cesar Salgado
Support Opportunities: Research Projects - Thematic Grants