Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis

Author(s)

Jackeline do Nascimento Tsurumaki ^[1] ; Luiz Guilherme Freitas de Paula ^[2] ; Sabrina Garcia de Aquino ^[3] ; Elcio Marcantonio Jr ^[4] ; Guilherme José Pimentel Lopes de Oliveira ^[5] ; Rosemary Adriana Chiérici Marcantonio ^[6]

Affiliation

^[1] Universidade Estadual Paulista. Faculdade de Odontologia de Araraquara. Departamento de Diagnóstico e Cirurgia - Brasil

^[2] Centro Universitário de Anápolis. Faculdade de Odontologia - Brasil

^[3] Universidade Federal da Paraíba. Faculdade de Odontologia. Departamento de Ciências da Saúde - Brasil

^[4] Universidade Estadual Paulista. Faculdade de Odontologia de Araraquara. Departamento de Diagnóstico e Cirurgia - Brasil

^[5] Universidade Federal de Uberlândia. Faculdade de Odontologia. Departamento de Periodontia - Brasil

^[6] Universidade Estadual Paulista. Faculdade de Odontologia de Araraquara. Departamento de Diagnóstico e Cirurgia - Brasil

• Document type: Journal article
• Source: Journal of Applied Oral Science; v. 27, 2019-09-09.

Abstract

Abstract Objective: This study aimed to evaluate the effect of avocado/soybean unsaponifiables (ASU) on periodontal repair in rats with induced periodontitis and arthritis. Methodology: Forty-five rats were submitted to periodontitis induction by insertion of ligatures into the upper second molars, maintained for 15 days. These animals were randomly allocated to 3 groups according to the presence of induced arthritis (ART) and the application of the ASU: Control (CTR) group-healthy animals, where saline solution was administered; ART-animals with induced arthritis, where saline solution was administered; ART/ASU-animals with induced arthritis, where ASU (0.6 mg/ kg) was administered. The drugs were administered daily by gavage and the animals were euthanized after 7, 15 and 30 days of the ligature removal. Bone resorption, inflammatory infiltrate composition and marker proteins expression of the differentiation and formation of osteoclasts (RANKL and TRAP) were assessed. Results: The ART/ASU group presented higher bone volume than the ART group at 7 and 30 days after the ligature removal. Furthermore, the ART group presented higher quantity of inflammatory cells and expression of TRAP and RANKL than the other groups. Conclusion: ASU administration improves the repair of periodontal tissues in an experimental periodontitis model in rats with induced arthritis. (AU)

• FAPESP's process: 09/17395-2 - Influence of avocado and soybean unsaponifiables in the induced periodontal disease and bone around integrated dental implants. Histological, radiographic and immuno-inflammatory analysis in rats.
• Grantee: Guilherme José Pimentel Lopes de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 10/13029-9 - Effect of avocado and soybean unsaponifiables on induced periodontal disease and osseointegration. Histological, radiological and immunohistochemistry in rats.
• Grantee: Rosemary Adriana Chierici Marcantonio
• Support Opportunities: Regular Research Grants