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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ADIPONECTIN, VITAMIN D AND NUTRITIONAL STATUS IN PATIENTS WITH ADVANCED COLORECTAL CANCER OR DURING FOLLOW-UP

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Author(s):
Mariana Abe Vicente CAVAGNARI [1] ; Verônica Marques VIDIGAL [2] ; Tiago Donizetti SILVA [3] ; Katia BARÃO [4] ; Nora Manoukian FORONES [5]
Total Authors: 5
Affiliation:
[1] Universidade Federal de São Paulo. Departamento de Medicina. Setor de Oncologia - Brasil
[2] Universidade Federal de São Paulo. Departamento de Medicina. Setor de Oncologia - Brasil
[3] Universidade Federal de São Paulo. Departamento de Medicina. Setor de Oncologia - Brasil
[4] Universidade Federal de São Paulo. Departamento de Medicina. Setor de Oncologia - Brasil
[5] Universidade Federal de São Paulo. Departamento de Medicina. Setor de Oncologia - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Arq. Gastroenterol.; v. 56, n. 2, p. 172-177, 2019-08-26.
Abstract

ABSTRACT BACKGROUND: Considering the high incidence of colorectal cancer (CRC) related deaths, many studies have investigated variables that can affect survival, with the aim of prolonging survival. The nutritional status can also be predict survival in patients with CRC. OBJECTIVE: The aim of the present study was to evaluate if BMI, %FAT, PhA, PG-SGA, adiponectin levels, and vitamin D levels are relevant to the characterization and differentiation of patients with advanced CRC and patients with a history of CRC. METHODS: The study was carried out by patients with advanced colorectal cancer (Group 1) and patients in follow-up after colorectal cancer treatment (Group 2). Nutritional status was assessed using the body mass index, body fat percentage, phase angle from bioelectrical impedance, Patient-Generated Subjective Global Assessment score. Adiponectin concentrations were determined using an enzyme-linked immunosorbent assay, and vitamin D levels were measured using high performance liquid chromatography. RESULTS: Groups 1 and 2 consisted of 23 and 27 patients, respectively. The body mass index, body fat percentage, phase angle, vitamin D and adiponectin levels were not significantly different between the groups. The mean Patient-Generated Subjective Global Assessment score was significantly higher in group 1 compared with group 2, and was significantly correlated with the long-term mortality risk. CONCLUSION: Among the nutritional status parameters, only the Patient-Generated Subjective Global Assessment score was significantly different between the groups and was an important predictor of survival in patients with advanced colorectal cancer. (AU)

FAPESP's process: 10/19191-2 - Analysis of the effectiveness of methods and indicators of nutritional status pertaining to patients with esophageal, gastric and colorectal cancer
Grantee:Nora Manoukian Forones
Support Opportunities: Regular Research Grants