The effectiveness of maternal pertussis vaccination in protecting newborn infants in Brazil: A case-control study

Author(s):Show less -

Fernandes, Eder Gatti ^[1] ; Sato, Ana Paula S. ^[2] ; Vaz-de-Lima, Lourdes R. A. ^[3] ; Rodrigues, Marcela ^[4] ; Leite, Daniela ^[5] ; de Brito, Cyro A. ^[3] ; Luna, Expedito J. A. ^[6] ; Carvalhanas, Telma Regina M. P. ^[4] ; Bacciote Nerger Ramos, Maria Ligia ^[7] ; Sato, Helena Keico ^[1] ; de Castilho, Euclides A. ^[8] ; de Souza, Edna M. ^[3] ; Atobe, Jane H. ^[3] ; Oliveira, Carmem A. F. ^[3] ; de Moraes, Jose Cassio ^[9] ; Gaspar, Jaqueline Correia ^[10] ; de Oliveira, Silvia Silva ^[11] ; Working, Maternal Pertussis Vaccine

Affiliation:Show less -

^[1] Secretaria Estado Saude Sao Paulo, Controle Doencas, Ctr Vigilancia Epidemiol Prof Alexandre Vranjac, Div Imunizacao, Av Dr Arnaldo 351, 6 Andar, BR-01246000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo - Brazil

^[3] Adolfo Lutz Inst, Ctr Imunol, Sao Paulo - Brazil

^[4] Secretaria Estado Saude Sao Paulo, Controle Doencas, Ctr Vigilancia Epidemiol Prof Alexandre Vranjac, Div Doencas Transmissao Resp, Sao Paulo - Brazil

^[5] Adolfo Lutz Inst, Ctr Bacteriol, Ctr Referencia Nacl Coqueluche, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Inst Med Trop, Sao Paulo - Brazil

^[7] Secretaria Municipal Saude Sao Paulo, Vigilancia Saude COVISA, Sao Paulo - Brazil

^[8] Univ Sao Paulo, Fac Med, Dept Med Prevent, Sao Paulo - Brazil

^[9] Fac Ciencias Med Santa Casa Sao Paulo, Sao Paulo - Brazil

^[10] Secretaria Estado Saude Sao Paulo, Controle Doencas, Ctr Vigilancia Epidemiol Prof Alexandre Vranjac, Nucleo Informacao Vigilancia Epidemiol, Sao Paulo - Brazil

^[11] Secretaria Municipal Saude Sao Paulo, Vigilancia Saude, Sao Paulo - Brazil

• Document type: Journal article
• Source: Vaccine; v. 37, n. 36, p. 5481-5484, AUG 23 2019.
• Web of Science Citations: 1

Abstract

Introduction: In 2014, the Brazilian Ministry of Health (MoH) recommended Tdap to pregnant women in response to a significant increase in the incidence of pertussis among infants. The present study assessed the effectiveness of maternal immunization in preventing pertussis in infants. Methods: An unmatched case-control study was undertaken in Sao Paulo State, Brazil from February 2015 to July 2016. Cases were infants aged <8 weeks at onset of pertussis reported to the Surveillance System and confirmed by real-time polymerase chain reaction or culture. Four to six healthy infants were selected as controls per case from birth certificates in the Information System on Live Births database. General characteristics and mother's vaccination status were compared between cases and controls. The vaccine effectiveness (VE) was calculated as 1 - odds ratio (OR). For the adjusted VE, the OR was calculated using logistic regression analysis. Results: Forty-two cases and 248 controls were enrolled in the study. Mothers of 8 cases (19.1%) and 143 controls (57.4%) were vaccinated during pregnancy, resulting in an unadjusted VE of 82.6% (95% confidence interval {[}CI], 60.8-92.3%). The VE was unchanged after adjusting for maternal age and monthly household income. Conclusion: Maternal pertussis vaccination during pregnancy was effective in protecting infants aged <8 weeks from pertussis. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 15/16157-1 - Influence of maternal vaccination with Tdap on children immune response
• Grantee: Euclides Ayres de Castilho
• Support Opportunities: Regular Research Grants