MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus

Author(s)

Gago Prata, Thamiris Vaz ^[1] ; Rodrigues da Silva, Dayane de Souza ^[1] ; Manchiero, Caroline ^[1] ; Dantas, Bianca Peixoto ^[1] ; Mazza, Celso Carmo ^[2] ; da Silva Nunes, Arielle Karen ^[1] ; Abdala, Edson ^[2] ; Figueiredo, Gerusa Maria ^[3] ; Tengan, Fatima Mitiko ^{[1, 2]} ; Magri, Mariana Cavalheiro ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Med Trop, Lab Invest Med Hepatol Virus LIM 47, Ave Dr Eneas de Carvalho Aguiar 470, Predio 2, BR-05403000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Molestias Infecciosas & Parasitarias, Inst Me, Ave Dr Eneas de Carvalho Aguiar 470, Predio 1, BR-05403000 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Inst Med Trop Sao Paulo, Inst Med Trop, Ave Dr Eneas de Carvalho Aguiar 470, Predio 1, BR-05403000 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: ARCHIVES OF VIROLOGY; v. 164, n. 10, p. 2559-2563, OCT 2019.
• Web of Science Citations: 0

Abstract

Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis. (AU)

• FAPESP's process: 16/19690-5 - Genetic changes in MTTP gene and its relation to plasma lipid levels and hepatic steatosis in patients with chronic hepatitis C
• Grantee: Mariana Cavalheiro Magri
• Support Opportunities: Regular Research Grants