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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Respiratory control of acid-base status in lungfish

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Author(s):
Nunan, Bruna L. C. Z. [1] ; Silva, Ayla S. [1] ; Wang, Tobias [2, 3] ; da Silva, Glauber S. F. [1]
Total Authors: 4
Affiliation:
[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Physiol & Biophys, Belo Horizonte, MG - Brazil
[2] Aarhus Univ, Aarhus Inst Adv Studies, Aarhus - Denmark
[3] Aarhus Univ, Dept Zoophysiol, Aarhus - Denmark
Total Affiliations: 3
Document type: Review article
Source: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY; v. 237, NOV 2019.
Web of Science Citations: 0
Abstract

The acid-base status is a tightly regulated physiological process, resulting from a balance of ions in the organism relevant to acid-base. The efficiency of the regulatory systems importantly determines the compensatory pH changes for a given disturb. Vertebrates minimize (or compensate) an acid-base disturb by general processes, which include ion transfer and/or PCO2 changes. Acid base adjustment in fish is predominantly achieved by branchial exchange of acid-base relevant ions with correlated change in plasma HCO3- levels. Conversely, land vertebrates change blood PCO2 through ventilatory process and hence respiratory control of acid base regulation plays an important role as a compensatory mechanism. Lungfishes (Dipnoi) have central position on vertebrate's evolution being considered as the sister group to the tetrapods. With an aquatic life mode, lungfish share similarities of respiratory function with tetrapods. This article reviews evidence showing that lungfish's respiratory system regulates acid-base status, like terrestrial ectothermic vertebrates. In the South American lungfish, Lepidosiren paradoxa, the presence of central CO2/pH chemoreceptors was unequivocally described. Also, the blood PCO2 and acid-base status are typical of a terrestrial vertebrate. These aspects are discussed under different environmental conditions that require respiratory acid-base adjustments, such as, exposure to hypercarbia, hypoxia, high temperature and aestivation. Interesting questions regarding the location and cell phenotype of CO2/pH central and peripheral chemoreceptors remain an open field to be explored in lungfish. (AU)

FAPESP's process: 13/17606-9 - Serotonin and respiratory control in vertebrates
Grantee:Glauber dos Santos Ferreira da Silva
Support type: Research Grants - Young Investigators Grants