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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of the urinary system in guinea pig females (Cavia porcellus)

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Author(s):
Santos, Amilton C. [1] ; Lisboa-Neto, Antonio F. S. [1] ; Silva, Ingrid K. L. [2] ; Pereira, Helton C. S. [1] ; Silveira, Julia M. [1] ; Silveira, Erick E. [1] ; Vasconcelos, Bruno G. [3] ; Assis-Neto, Antonio C. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Rua Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[2] Ctr Univ Fundacao Ensino Octavio Bastos UniFEOB, Av Dr Octavio Bastos, BR-13870000 Sao Joao Da Boa Vista, SP - Brazil
[3] Univ Fed Vales Jequitinhonha & Mucuri, Av Vereador Joao Narciso 1380, BR-38610000 Unai, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 39, n. 7, p. 549-560, JUL 2019.
Web of Science Citations: 0
Abstract

ABSTRACT: Guinea pigs are animal models widely used in research related to developmental biology. The objective of this work was to demonstrate the process of formation and differentiation of urinary organs in females of the species in the prenatal period. Four females were used at 25, 30, 45 and >65 DG (days of gestation). The animals were dissected, and then macroscopic and microscopic descriptions of the urinary organs were performed. At 25 DG metanephros were present in the urogenital crest into the abdominal cavity. Collecting ducts and glomerular precursor cells could be visualized. After this period, metanephros underwent microstructural modifications to form the kidneys at the end of the prenatal period. After 30 DG, the renal parenchyma already had a cortex, where the glomerulus and proximal convoluted tubules were present; and the medulla, where distal convoluted tubules, collecting ducts, and pelvis were present. The pelvis of each kidney was drained by the ureters. The ureters also underwent tissue differentiation to be differentiated (mucosa with transitional epithelium and lamina propria of connective tissue, muscular, and adventitia) at the end of the prenatal period. The urinary vesicle also underwent tissue changes to form the tunics similar to those found in the ureters, with emphasis on the greater volume of the muscular tunica and the lamina propria that constituted the submucosa in this organ. The pelvic urethra was evidenced by a mucosa lined by transitional epithelium, submucosa, muscular and adventitia. Finally, a partial clitoral urethra and a urethral meatus in the prepuce of the clitoris were also evidenced. The urethral channel began to form with the emergence of the urethral plate and the urethral groove at 30 DG and thereafter with the fusion of the urethral folds to form a partially channeled urethra in the clitoris. A urethral meatus was observed in the most distal portion of the clitoral tissue, formed by the fusion of the prepuce. It is concluded that the urinary organs of guinea pig have similar development to that described in domestic animals, except for the partial clitoral urethra and evident urethral meatus. (AU)

FAPESP's process: 16/24040-0 - Morphological, morphometric and steroidogenic parameters of the sexual differentiation of the external genitalia in Galea spixii
Grantee:Amilton Cesar dos Santos
Support Opportunities: Scholarships in Brazil - Post-Doctoral