Evaluation of Cardiac Autonomic Modulation Using Symbolic Dynamics After Cardiac Transplantation

Author(s)

Garcia de Moura-Tonello, Silvia Cristina ^[1] ; Carvalho, Vitor Oliveira ^[2] ; de Godoy, Moacir Fernandes ^{[3, 4]} ; Porta, Alberto ^{[5, 6]} ; de Oliveira Leal, Angela Merice ^[7] ; Bocchi, Edimar Alcides ^[8] ; Catai, Aparecida Maria ^[1]

Affiliation

^[1] Fed Univ Sao Carlos UFSCar, Cardiovasc Physiotherapy Lab LFCV, Physiotherapy Dept, Rod Washington Luiz, S-N, BR-13565905 Sao Carlos, SP - Brazil

^[2] Fed Univ Sergipe UFS, Physiotherapy Dept, Sao Cristovao, SE - Brazil

^[3] Med Sch Sao Jose Rio Preto FAMERP, Cardiol & Cardiovasc Surg Dept, Sao Jose Do Rio Preto, SP - Brazil

^[4] Med Sch Sao Jose do Rio Preto FAMERP, Transdisciplinary Nucleus Study Chaos & Complex N, Sao Jose Do Rio Preto, SP - Brazil

^[5] IRCCS Policlin San Donato, Dept Cardiothorac Vasc Anesthesia & Intens Care, Milan - Italy

^[6] Univ Milan, Dept Biomed Sci Hlth, Milan - Italy

^[7] Fed Univ Sao Carlos UFSCar, Dept Med, Sao Paulo - Brazil

^[8] Univ Sao Paulo, InCor HC FMUSP, Fac Med, Inst Coracao Hosp Clin, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Revista Brasileira de Cirurgia Cardiovascular; v. 34, n. 5, p. 572-580, 2019.
• Web of Science Citations: 0

Abstract

Abstract Objective: To characterize the behavior of cardiac autonomic modulation in individuals with different times after orthotopic heart transplantation (HTx) using symbolic dynamics analysis. Methods: Sixty patients were evaluated after HTx. We recorded their instantaneous R-R intervals (RRi) by cardiac monitor Polar® RS800CX™ (Polar Electro Oy, Kempele, Finland) for 10 minutes. The same sequence of RRi with 256 consecutive beats was used to perform spectral analysis and symbolic dynamics analysis. We used hierarchical clustering to form groups. One-way analysis of variance (ANOVA) (with Holm-Sidak method) or one-way Kruskal-Wallis test (with Dunn´s post-hoc test) was used to analyze the difference between groups. Linear correlation analysis between variables was performed using Pearson’s or Spearman’s tests. P-value < 0.05 was considered statistically significant. Results: The 0V% index increased, the 2UV% index and the normalized complexity index decreased with an increase of HTx postoperative time. There were a negative correlation between complexity indexes and 0V% and a positive correlation between complexity indexes and 2UV%. Conclusion: Symbolic dynamics indexes were able to show a specific cardiac autonomic modulation pattern for HTx recipients with different postoperative times. (AU)

• FAPESP's process: 10/01361-9 - Comparative study of diastolic heart function, autonomic balance and exercise capacity among groups of individuals in different years of follow-up after heart transplantation
• Grantee: Edimar Alcides Bocchi
• Support Opportunities: Regular Research Grants