Mitochondria as central hub of the immune system

Author(s)

de Souza Breda, Cristiane Naffah ^[1] ; Davanzo, Gustavo Gastao ^[2] ; Basso, Paulo Jose ^[1] ; Saraiva Camara, Niels Olsen ^[1] ; Mendes Moraes-Vieira, Pedro Manoel ^[2]

Affiliation

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Transplantat Immunobiol Lab, Ave Prof Lineu Prestes 1730, ICB 4, Sala 238, BR-05508000 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Lab Immunometab, Dept Genet Evolut Microbiol & Immunol, Inst Biol, St Monteiro Lobato 255, Cidade Univ Zeferino Vaz, BR-13083970 Campinas, SP - Brazil

• Document type: Review article
• Source: REDOX BIOLOGY; v. 26, SEP 2019.
• Web of Science Citations: 4

Abstract

Nearly 130 years after the first insights into the existence of mitochondria, new rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell fate, mitochondria integrate cell physiology, signaling pathways and metabolism. Thus, recent research has focused on understanding how these multifaceted functions can be used to improve inflammatory responses and prevent cellular dysfunction. Here, we describe the role of mitochondria on the development and function of immune cells, highlighting metabolic aspects and pointing out some metabolic- independent features of mitochondria that sustain cell function. (AU)

• FAPESP's process: 15/26682-6 - Evaluation of mTOR on energy metabolism and activation of B cells during experimental intestinal inflammation
• Grantee: Paulo José Basso
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/15626-8 - Macrophages and T lymphocytes immunometabolism in metabolic and inflammatory diseases
• Grantee: Pedro Manoel Mendes de Moraes Vieira
• Support type: Research Grants - Young Investigators Grants
• FAPESP's process: 16/18031-8 - HIF-1 alpha in metabolic and functional control of adipose tissue resident macrophages from in diabetes induced by obesity
• Grantee: Gustavo Gastão Davanzo
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 14/10910-7 - mTOR signaling pathway in neutrophils during inflammation experimental model associated with obesity
• Grantee: Cristiane Naffah de Souza
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
• Grantee: Niels Olsen Saraiva Câmara
• Support type: Research Projects - Thematic Grants