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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mitochondria as central hub of the immune system

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de Souza Breda, Cristiane Naffah [1] ; Davanzo, Gustavo Gastao [2] ; Basso, Paulo Jose [1] ; Saraiva Camara, Niels Olsen [1] ; Mendes Moraes-Vieira, Pedro Manoel [2]
Total Authors: 5
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Transplantat Immunobiol Lab, Ave Prof Lineu Prestes 1730, ICB 4, Sala 238, BR-05508000 Sao Paulo - Brazil
[2] Univ Estadual Campinas, Lab Immunometab, Dept Genet Evolut Microbiol & Immunol, Inst Biol, St Monteiro Lobato 255, Cidade Univ Zeferino Vaz, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: REDOX BIOLOGY; v. 26, SEP 2019.
Web of Science Citations: 4

Nearly 130 years after the first insights into the existence of mitochondria, new rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell fate, mitochondria integrate cell physiology, signaling pathways and metabolism. Thus, recent research has focused on understanding how these multifaceted functions can be used to improve inflammatory responses and prevent cellular dysfunction. Here, we describe the role of mitochondria on the development and function of immune cells, highlighting metabolic aspects and pointing out some metabolic- independent features of mitochondria that sustain cell function. (AU)

FAPESP's process: 15/26682-6 - Evaluation of mTOR on energy metabolism and activation of B cells during experimental intestinal inflammation
Grantee:Paulo José Basso
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/15626-8 - Macrophages and T lymphocytes immunometabolism in metabolic and inflammatory diseases
Grantee:Pedro Manoel Mendes de Moraes Vieira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 16/18031-8 - HIF-1 alpha in metabolic and functional control of adipose tissue resident macrophages from in diabetes induced by obesity
Grantee:Gustavo Gastão Davanzo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/10910-7 - mTOR signaling pathway in neutrophils during inflammation experimental model associated with obesity
Grantee:Cristiane Naffah de Souza
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants