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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer's disease patients

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Author(s):
HELENA P. G. JOAQUIM ; ALANA C. COSTA ; ORESTES V. FORLENZA ; WAGNER F. GATTAZ ; LEDA L. TALIB
Total Authors: 5
Document type: Journal article
Source: ARCHIVES OF CLINICAL PSYCHIATRY; v. 46, n. 5, p. 120-124, Out. 2019.
Web of Science Citations: 0
Abstract

Abstract Background Current evidence suggests that upregulation of polyamines system plays a role both in cognitive deficit and synaptic loss observed in Alzheimer’s disease (AD). Objective The aim of this study was to determine the plasmatic concentration of polyamines in mild cognitive impairment (MCI) and AD patients in comparison with healthy controls (HC). Methods Plasmatic polyamines were quantified using the AbsoluteIDQ® p180 and liquid chromatography coupled to tandem mass spectrometry (LC/MS-MS). Results The study group comprised 34 AD patients, 20 MCI and 25 HC. All individuals were followed for 4 years. During this period 8 amnestic MCI patients (40% of the MCI sample at baseline) converted to AD. Spermidine level was lower in both patient groups (AD; MCI) compared to HC (p = 0.007). Plasma levels of spermine were higher in the MCI group (p < 0.001), but decreased in the sub-sample of MCI patients who converted to AD (p = 0.043). No statistically significant differences were found in ornithine and putrescine levels (p = 0.056 and p = 0.126, respectively). Discussion Our results suggest dynamic changes in the expression of polyamines in the MCI-AD continuum. (AU)

FAPESP's process: 14/50873-3 - INCT 2014: National Institute of Biomarkers in Neuropsychiatry
Grantee:Wagner Farid Gattaz
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/20913-3 - Determination of plasma phospholipids in neuropsychiatric disorders
Grantee:Alana Caroline Costa
Support type: Scholarships in Brazil - Master