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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Myosteatosis in a systemic inflammation-dependent manner predicts favorable survival outcomes in locally advanced esophageal cancer

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Author(s):
Gabiatti, Camila T. B. [1] ; Martins, Marian C. L. [1] ; Miyazaki, Daniela L. [1] ; Silva, Leandro P. [1] ; Lascala, Fabiana [1] ; Macedo, Ligia T. [1] ; Santos Mendes, Maria Carolina [1] ; Campello Carvalheira, Jose Barreto [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Div Oncol, Dept Internal Med, Fac Med Sci, UNICAMP, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CANCER MEDICINE; v. 8, n. 16, p. 6967-6976, NOV 2019.
Web of Science Citations: 0
Abstract

Increased adiposity and its attendant metabolic features as well as systemic inflammation have been associated with prognosis in locally advanced esophageal cancer (LAEC). However, whether myosteatosis and its combination with systemic inflammatory markers are associated with prognosis of esophageal cancer is unknown. Our study aimed to investigate the influence of myosteatosis and its association with systemic inflammation on progression-free survival (PFS) and overall survival (OS) in LAEC patients treated with definitive chemoradiotherapy (dCRT). We retrospectively gathered information on 123 patients with LAEC submitted to dCRT at the University of Campinas Hospital. Computed tomography (CT) images at the level of L3 were analyzed to assess muscularity and adiposity. Systemic inflammation was mainly measured by calculating the neutrophil-to-lymphocyte ratio (NLR). Median PFS for patients with myosteatosis (n = 72) was 11.0 months vs 4.0 months for patients without myosteatosis (n = 51) (hazard ratio {[}HR]: 0.53; 95% confidence interval {[}CI], 0.34-0.83; P = .005). Myosteatosis was also independently associated with a favorable OS. Systemic inflammation (NLR > 2.8) was associated with a worse prognosis. The combination of myosteatosis with systemic inflammation revealed that the subgroup of patients with myosteatosis and without inflammation presented less than half the risk of disease progression (HR: 0.47; 95% CI: 0.26-0.85; P = .013) and death (HR: 0.39; 95% CI, 0.21-0.72; P = .003) compared with patients with inflammation. This study demonstrated that myosteatosis without systemic inflammation was independently associated with favorable PFS and OS in LAEC patients treated with dCRT. (AU)

FAPESP's process: 18/23428-0 - Metabolic profile characterization of sarcopenic patients with colorectal cancer
Grantee:José Barreto Campello Carvalheira
Support Opportunities: Regular Research Grants