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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sensory and Motor Conduction Velocity in Spontaneously Hypertensive Rats: Sex and Aging Investigation

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Author(s):
Fontanesi, Lucas B. [1] ; Fazan, Frederico S. [2] ; Dias, Fernando J. [3] ; Schiavoni, Maria Cristina L. [1] ; Marques Jr, Wilson ; Sassoli Fazan, Valeria Paula [4, 5]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Neurosci & Behav Sci, Ribeirao Preto - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Paulista Sch Med, Dept Physiol, Sao Paulo, SP - Brazil
[3] Univ La Frontera UFRo, Dent Sch, CICO Res Ctr Dent Sci, Dept Integral Dent, Temuco - Chile
[4] Marques Jr, Jr., Wilson, Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Neurosci & Behav Sci, Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Surg & Anat, Ribeirao Preto - Brazil
Total Affiliations: 5
Document type: Journal article
Source: FRONTIERS IN SYSTEMS NEUROSCIENCE; v. 13, NOV 1 2019.
Web of Science Citations: 0
Abstract

The literature is extensive on how hypertension affects the morphology and function of the central nervous system (CNS) and is being focused on multiple organ damage involving the kidneys, heart, endothelium and retina. Hypertension damage to the peripheral nervous system is less explored in the literature. We have previously shown morphometric alterations in large and small caliber myelinated fibers of nerves in the adult spontaneously hypertensive rat (SHR). However, the functional correlation of these findings has not been explored. We performed an electrophysiological investigation of hind limb nerves in SHR of both genders in different ages. Normotensive Wistar-Kyoto (WKY) rats were used as controls. Electrophysiological recordings and determination of motor (MCV) and sensory (SCV) nerve conduction velocity were performed in the same animals at four different ages: 5, 8, 20 and 40 weeks after birth. Comparisons were made between ages, genders and animal strain. We showed a continuous body weight increase in adult life in all animals studied. MCV got stable at 20-week old hypertensive animals and continued to increase in normotensive ones. The SCV was constant between the ages of 20 and 40 weeks old in female SHR and decreased in male SHR while it continued to increase in WKY animals. The electrophysiological investigation of the nerves in WKY and SHR from both genders and different ages, associated with morphological and morphometric data from the literature suggest that hypertension affects the nerve function and might corroborate the development of a peripheral neuropathy. (AU)

FAPESP's process: 13/01111-0 - Sensory and motor conduction velocity in spontaneously hypertensive rats
Grantee:Valéria Paula Sassoli Fazan
Support Opportunities: Regular Research Grants