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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

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Author(s):
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Hall, Amy L. [1] ; Kromhout, Hans [2] ; Schuz, Joachim [1] ; Peters, Susan [2] ; Portengen, Lutzen [2] ; Vermeulen, Roel [1] ; Agudo, Antonio [3] ; Ahrens, Wolfgang [4, 5] ; Boffetta, Paolo [6, 7] ; Brennan, Paul [1] ; Canova, Cristina [8] ; Conway, I, David ; Curado, Maria Paula [9] ; Daudt, Alexander W. [10] ; Fernandez, Leticia [11] ; Hashibe, Mia [12] ; Healy, Claire M. [13] ; Holcatova, Ivana [14] ; Kjaerheim, Kristina [15] ; Koifman, Rosalina [16] ; Lagiou, Pagona [17] ; Luce, Daniele [18] ; Macfarlane, Gary J. [19] ; Menezes, Ana [20] ; Menvielle, Gwenn [21] ; Polesel, Jerry [22] ; Ramroth, Heribert [23] ; Richiardi, Lorenzo [24] ; Stucker, Isabelle [25] ; Thomson, Peter [26] ; Vilensky, Marta [27] ; Wunsch-Filho, Victor [28] ; Yuan-Chin, Amy Lee [12, 29] ; Znaor, Ariana [1] ; Straif, Kurt [1] ; Olsson, Ann [1]
Total Authors: 36
Affiliation:
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[1] Int Agcy Res Canc, Lyon - France
[2] Univ Utrecht, Inst Risk Assessment Sci, Utrecht - Netherlands
[3] Catalan Inst Oncol IDIBELL, Unit Nutr & Canc, Canc Epidemiol Res Program, Barcelona - Spain
[4] Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen - Germany
[5] Univ Bremen, Fac Math Comp Sci, Inst Stat, Bremen - Germany
[6] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA
[7] Univ Bologna, Dept Med & Surg Sci, Bologna - Italy
[8] Univ Padua, Padua - Italy
[9] Epidemiol CIPE ACCAMARGO, Sao Paulo, SP - Brazil
[10] Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil
[11] Inst Oncol & Radiobiol, Havana - Cuba
[12] Univ Utah, Salt Lake City, UT - USA
[13] Trinity Coll Dublin, Sch Dent Sci, Dublin - Ireland
[14] Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Prague - Czech Republic
[15] Inst Populat Based Canc Res, Canc Registry Norway, Oslo - Norway
[16] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro - Brazil
[17] Univ Athens, Sch Med, Athens - Greece
[18] Univ Rennes, Irset, UMR S 1085, EHESP, Inserm, Pointe A Pitre, Guadeloupe - France
[19] Univ Aberdeen, Sch Med Med Sci & Nutr, Epidemiol Grp, Aberdeen - Scotland
[20] Univ Fed Pelotas, Pelotas, RS - Brazil
[21] Sorbonne Univ, IPLESP, INSERM, Paris - France
[22] Aviano Canc Ctr, Aviano - Italy
[23] Heidelberg Univ, Heidelberg - Germany
[24] Univ Turin, Dept Med Sci, Turin - Italy
[25] Paris Saclay Univ, Univ Paris Sud, Environm Epidemiol Canc Team, UVSQ, CESP, INSERM, Villejuif - France
[26] Univ Hong Kong, Hong Kong - Peoples R China
[27] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF - Argentina
[28] Univ Sao Paulo, Sao Paulo, SP - Brazil
[29] Univ Utah, Div Publ Hlth, Dept Family & Prevent Med, Sch Med, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108 - USA
Total Affiliations: 29
Document type: Journal article
Source: EPIDEMIOLOGY; v. 31, n. 1, p. 145-154, JAN 2020.
Web of Science Citations: 0
Abstract

Introduction: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders. Methods: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the International Head and Neck Cancer Epidemiology Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989 to 2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined) and females (asbestos and respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant. Results: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, P values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined); strongest associations were for asbestos at >90th percentile cumulative exposure (OR = 1.3, 95% confidence interval {[}CI] = 1.0, 1.6), respirable crystalline silica at 30+ years duration (OR = 1.4, 95% CI = 1.2, 1.7) and 75th-90th percentile cumulative exposure (OR = 1.4, 95% CI = 1.1, 1.8), chromium-VI at >75th percentile cumulative exposure (OR = 1.9, 95% CI = 1.2, 3.0), and chromium-VI and nickel combined at 20-29 years duration (OR = 1.5, 95% CI = 1.1, 2.2). Conclusions: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer. (AU)