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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The modulatory effect of triclosan on the reversion of the activated phenotype of LX-2 hepatic stellate cells

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Author(s):
Miranda, Juliana F. [1] ; Scarinci, Leticia D. [1] ; Ramos, Leticia F. [1] ; Silva, Caio M. [1] ; Goncalves, Leticia R. [1] ; de Morais, Priscila F. [1] ; Malaspina, Osmar [2] ; Moraes, Karen C. M. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista, Dept Biol, Inst Biociencias, Campus Rio Claro, Rio Claro, SP - Brazil
[2] Univ Estadual Paulista, Ctr Estudos Insetos Sociais, Inst Biociencias, Rio Claro, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY; v. 34, n. 1 JAN 2020.
Web of Science Citations: 0
Abstract

Hepatic diseases leading to fibrosis affect millions of individuals worldwide and are a major public health challenge. Although, there have been many advances in understanding hepatic fibrogenesis, an effective therapy remains elusive. Studies focus primarily on activation of the hepatic stellate cells (HSCs), the principal fibrogenic cells in the liver; however, fewer numbers of studies have examined molecular mechanisms that deactivate HSC, controlling the profibrogenic phenotype. In the present study, we evaluated cellular and molecular actions of the chemical triclosan (TCS) in reverting activated HSCs to a quiesced phenotype. We demonstrated that the inhibition of the enzyme fatty acid synthase by TCS in activated HSCs promotes survival of the cells and triggers cellular and molecular changes that promote cellular phenotypic reversion, offering potentially new therapeutic directions. (AU)

FAPESP's process: 13/21186-5 - Molecular networks regulated by small non-coding RNAs in hepatic fibrosis process and their modulatory effect of the vasoactive peptide angiotensin-(1-7)
Grantee:Karen Cristiane Martinez de Moraes
Support Opportunities: Regular Research Grants
FAPESP's process: 18/05286-3 - Mechanistic and functional analyses of the microRNA-1914-5p in the nonalcoholic hepatic pro-steatotic processes in cell culture model
Grantee:Karen Cristiane Martinez de Moraes
Support Opportunities: Regular Research Grants