| Grant number: | 13/21186-5 |
| Support Opportunities: | Regular Research Grants |
| Start date: | March 01, 2014 |
| End date: | August 31, 2016 |
| Field of knowledge: | Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms |
| Principal Investigator: | Karen Cristiane Martinez de Moraes |
| Grantee: | Karen Cristiane Martinez de Moraes |
| Host Institution: | Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil |
| City of the host institution: | Rio Claro |
| Associated researchers: | Bruno Cogliati ; Carol Jane Wilusz ; Igor Jurisica |
Abstract
Understand the fine-tunning of gene expression that keeps the organism integrity has been considered a focus of investigation in several research areas. In this context, to investigate small non-coding RNAs (sncRNAs), more precisely microRNAs (miRNAs), is considered a hot spot in science nowadays. Those small molecules modulate gene expression and studies have appointed its future use in drug development by pharmaceutical companies. In fact, in order to miRNA could be used in clinical, a detailed mechanistic function of those molecules and molecular networks must be elucidated. Actually, hepatic fibrosis is still considered a serious problem in public health and the development of new therapies are major goal. More recently studies demonstrated a potential antifibrotic activity of the vasoactive peptide Angiotensina-(1-7) [(Ang-(1-7)], which was also appointed as a strong candidate in modulatting the level and activity of the cyclooxygenase-2 (COX-2) protein. COX-2 is the major enzyme responsible for the controlling of the inflammatory process, wich directly or indirectly correlates with the fibrotic process. However, the network of molecular mechanisms in hepatic fibrosis and its modulation by the vasoactive peptide still been a matter of investigation. Based on the exposed, the identification of central elements in liver fibrotic pathway and their correlations with miRNAs will probably redirects clinical trials. For that, cellular assays, qRT-PCRs, next generation sequencing, molecular interactions validations, Western blots, RNA interference, and bioinformatic analyses will be performed. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |