Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Risk factors for fixed airflow obstruction in children and adolescents with asthma: 4-Year follow-up

Full text
Sousa, Andrey W. [1] ; Barros Cabral, Anna L. [2] ; Arruda Martins, Milton [3] ; Carvalho, Celso R. F. [1]
Total Authors: 4
[1] Univ Sao Paulo, Sch Med, Dept Phys Therapy, Sao Paulo, SP - Brazil
[2] Darcy Vargas Childrens Hosp, Dept Pulmonol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Clin Med, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PEDIATRIC PULMONOLOGY; v. 55, n. 3 JAN 2020.
Web of Science Citations: 0

Background Asthma is a disease with reversible bronchoconstriction; however, some patients develop fixed airflow obstruction (FAO). Previous studies have reported the incidence and risk factors of FAO in adults; however, the corresponding factors in children remain poorly understood. Aim To evaluate the incidence and risk factors of FAO in children and adolescents with asthma. Method Observational and prospective cohort study with a 4-year follow-up of clinically stable patients with asthma (from 6-8 years old). Anthropometric data, history of asthma, number of hospitalizations, frequent exacerbations, asthma severity, asthma control, inhaled corticosteroid dose, atopy, and lung function were analyzed as potential risk factors for FAO. FAO was defined by a ratio of the forced expiratory volume in the first second to the forced vital capacity below the lower limit of normal, even after inhaled and oral corticosteroid treatment. Results Four hundred and twenty-eight patients were recruited, and 358 were analyzed. The FAO incidence in children and adolescents with asthma was 9.5% (n = 34), starting at 10 years of age. Age, body mass index, hospitalizations for asthma, bronchodilator response, frequent exacerbations, length of exacerbations, and asthma severity were associated with FAO. Frequent exacerbations (odds ratio {[}OR] = 4.0; 95% confidence interval {[}CI] = 1.3-11.7) and asthma severity categorized as steps 4 to 5 (OR = 3.5; 95% CI = 1.6-7.6) remained risk factors. Conclusions Frequent exacerbations and asthma severity are the risk factors for FAO in children and adolescents with asthma. (AU)

FAPESP's process: 16/05968-1 - New approaches to evaluate patients with chronic obstructive respiratory diseases
Grantee:Celso Ricardo Fernandes de Carvalho
Support Opportunities: Regular Research Grants