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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies

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Author(s):
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Tholance, Yannick [1, 2] ; Moritz, Christian Peter [1] ; Rosier, Carole [1, 3] ; Ferraud, Karine [3] ; Lassabliere, Francois [1] ; Reynaud-Federspiel, Evelyne [1] ; Franca, Jr., Marcondes C. [4] ; Martinez, Alberto R. M. [4] ; Camdessanche, Jean-Philippe [1, 3] ; Antoine, Jean-Christophe [1, 3] ; Adams, David [5] ; Cauquil, Cecile [5] ; Attarian, Shahram [6] ; Delmont, Emilien [6] ; Blanchet-Fourcade, Genevieve [7] ; Callias, Celine [8] ; Cassereau, Julien [9] ; Choumert, Ariane [10] ; Clavelou, Pierre [11] ; Creange, Alain [12] ; Di Virgilio, Gabriella [13] ; Echaniz-Laguna, Andoni [14] ; Faucher, Benoit [15] ; Galea, Ian [16] ; Genestet, Steeve [17] ; Gueguen, Antoine [18] ; Ion, Ioana M. [19] ; Juntas-Morales, Raul [20] ; Taieb, Guillaume [20] ; Kuntzer, Thierry [21] ; Lagrange, Emmeline [22] ; Leger, Jean-Marc [23] ; Stojkovic, Tanya [23] ; Lepetit, Maud [24] ; Magy, Laurent [25] ; Mas, Julie [26] ; Michaud, Maud [27] ; Mouthon-Reignier, Capucine [28] ; Neau, Jean-Philippe [29] ; Ozsancak, Canan [30] ; Pereon, Yann [31] ; Perrotte, Paul [32] ; Puma, Angela [33, 34] ; Rajabally, Yusuf A. [35] ; Rinaldi, Simon [36] ; Rouaud, Violaine [37] ; Sole, Guilhem [38] ; Tard, Celine [39] ; Vallet, Anne-Evelyne [40] ; Vial, Christophe [41] ; Grp, Anti-FGFR3 Antibody Study
Total Authors: 51
Affiliation:
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[1] Inst Neuromyogene, Synaptopathies & Autoanticorps Synatac, St Priest En Jarez - France
[2] CHU St Etienne, Lab Biochem, F-42055 St Etienne - France
[3] CHU St Etienne, Dept Neurol, St Etienne - France
[4] Univ Campinas UNICAMP, Dept Neurol, Campinas, SP - Brazil
[5] Univ Paris Sud, Kremlin Bicetre Hosp, AP HP, FILNEMUS, Dept Neurol, Le Kremlin Bicetre - France
[6] Aix Marseille Univ, Univ Hosp La Timone, Reference Ctr Neuromuscular Disorders & ALS, Marseille - France
[7] Hosp Ctr Narbonne, Dept Neurol, Narbonne - France
[8] Valais Hosp, Cent Inst Hosp ICH, Dept Neurol, Sion - Switzerland
[9] Univ Hosp Angers, ALS Ctr, Dept Neurol, Angers - France
[10] Univ Hosp Reunion, Dept Neurol, St Pierre, Reunion - France
[11] Univ Hosp Clermont Ferrand, Dept Neurol, Clermont Ferrand - France
[12] Henri Mondor Univ Hosp, CHU Creteil, Dept Neurol, Creteil - France
[13] RivieraChablais Hosp, Dept Neurol, Vevey - Switzerland
[14] Univ Hosp Strasbourg, Dept Neurol, Strasbourg - France
[15] Toulon La Seyne Sur Mer Intercommunal Hosp Ctr, Dept Multidisciplinary Med, Toulon - France
[16] Univ Hosp Southampton NHS Fdn Trust, Wessex Neurosci Ctr, Southampton, Hants - England
[17] Univ Hosp Brest, Dept Neurol Funct Explorat, Brest - France
[18] Fdn Ophtalmol Adolphe Rothschild, Dept Neurol, Paris - France
[19] Univ Hosp Nimes, Dept Neurol, Nimes - France
[20] Univ Hosp Montpellier, Dept Neurol, Montpellier - France
[21] CHU Vaudois, Univ Lausanne Hosp, Dept Neurol, Lausanne - Switzerland
[22] Univ Hosp Grenoble, Dept Neurol, Grenoble - France
[23] Univ Hosp Pitie Salpetriere, Natl Referral Ctr Neuromuscular Dis, Paris - France
[24] Cornouailles Hosp Ctr, Dept Neurol, Quimper - France
[25] Univ Hosp Limoges, Reference Ctr Rare Peripheral Neuropathies, Dept Neurol, Limoges - France
[26] St Jean Hosp, Dept Neurol, Perpignan - France
[27] Univ Hosp Nancy, Dept Neurol, Nancy - France
[28] Sud Francilien Hosp Ctr, Dept Neurol, Corbeil Essonnes - France
[29] Univ Poitiers Hosp, Dept Neurol, Poitiers - France
[30] Reg Hosp Ctr Orleans, Dept Neurol, Orleans - France
[31] Hop Hotel Dieu, Ctr Neuromuscular Dis, Nantes - France
[32] Hosp Ctr Le Havre, Dept Neurol, Le Havre - France
[33] Univ Nice, Peripheral Nervous Syst Muscle & ALS Dept, Nice - France
[34] Univ Cote Azur, Nice - France
[35] Univ Hosp Birmingham, Queen Elizabeth Hosp, Reg Neuromuscular Clin, Birmingham, W Midlands - England
[36] Univ Oxford, John Radcliffe Hosp Oxford, Nuffield Dept Clin Neurosci, Oxford Autoimmune Neurol Grp, Oxford - England
[37] Bretagne Atlantique Hosp Ctr, Dept Neurol, Vannes - France
[38] Univ Hosp Bordeaux, Dept Neurol, Bordeaux - France
[39] Lille Univ, Med Ctr, Dept Neurol & Movement Disorders, Lille - France
[40] Hosp Ctr Vienne, Dept Neurol, Vienne - France
[41] Hosp Civils Lyon, Neuromuscular Reference Ctr, Bron - France
Total Affiliations: 41
Document type: Journal article
Source: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY; v. 91, n. 1, p. 49-57, JAN 2019.
Web of Science Citations: 3
Abstract

Objective Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN. Methods A prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres ('center-matched'). Results Sixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5-6 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p<0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95% CI 3.4 to 8424). Conclusions Anti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors. (AU)

FAPESP's process: 13/26410-0 - Clinical, immunological and neurophysiological characterization of sensory neuronopathies
Grantee:Alberto Rolim Muro Martinez
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/01766-7 - Sensory neuronopathies: investigation of new diagnostic methods, mechanisms of the disease and therapeutic strategies
Grantee:Marcondes Cavalcante Franca Junior
Support Opportunities: Research Grants - Young Investigators Grants