| Full text | |
| Author(s): |
Siden-Kiamos, Inga
[1]
;
Goosmann, Christian
[2]
;
Buscaglia, Carlos A.
[3]
;
Brinkmann, Volker
[2]
;
Matuschewski, Kai
[2, 4]
;
Montagna, Georgina N.
[2, 3, 5]
Total Authors: 6
|
| Affiliation: | [1] Fdn Res & Technol, Inst Mol Biol & Biotechnol, Iraklion 70013, Crete - Greece
[2] Max Planck Inst Infect Biol, D-10117 Berlin - Germany
[3] UNSAM CONICET, Inst Invest Biotecnol Dr Rodolfo Ugalde IIBio, RA-1650 San Martin, Buenos Aires - Argentina
[4] Humboldt Univ, Inst Biol, Dept Mol Parasitol, D-10117 Berlin - Germany
[5] Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, BR-049032 Sao Paulo, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Molecular and Biochemical Parasitology; v. 235, JAN 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Gliding motility and cell invasion are essential for the successful transmission of Plasmodium parasites. These processes rely on an acto-myosin motor located underneath the parasite plasma membrane. The Myosin A-tail interacting protein (MTIP) connects the class XIV myosin A (MyoA) to the gliding-associated proteins and is essential for assembly of the motor at the inner membrane complex. Here, we assessed the subcellular localization of MTIP in Plasmodium berghei motile stages from wild-type parasites and mutants that lack MyoA or the small heat shock protein 20 (HSP20). We demonstrate that MTIP is recruited to the apical end of motile ookinetes independently of the presence of MyoA. We also show that infective sporozoites displayed a polarized MTIP distribution during gliding, and that this distribution was abrogated in mutant parasites with an aberrant locomotion. (AU) | |
| FAPESP's process: | 13/14361-5 - Plasmodium parasite motility: identification of new candidates for drug targeting and validation of vaccine candidates |
| Grantee: | Georgina Nuri Montagna |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/07138-0 - Plasmodium parasite motility: identification of new candidates for drug targeting and validation of vaccine candidates |
| Grantee: | Georgina Nuri Montagna |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |