Plasma Lipid Profile and Systemic Inflammation in Patients With Cancer Cachexia

Author(s):Show less -

dos Reis Riccardi, Daniela Mendes ^[1] ; das Neves, Rodrigo Xavier ^[2] ; de Matos-Neto, Emidio Marques ^{[1, 3]} ; Camargo, Rodolfo Gonzalez ^[1] ; Carola Correia Lima, Joanna Darck ^[1] ; Radloff, Katrin ^[1] ; Alves, Michele Joana ^[1] ; Figueredo Costa, Raquel Galvao ^[1] ; Tokeshi, Flavio ^[4] ; Otoch, Jose Pinhata ^{[5, 4]} ; Maximiano, Linda Ferreira ^{[5, 4]} ; Martins de Alcantara, Paulo Sergio ^[4] ; Colquhoun, Alison ^[6] ; Laviano, Alessandro ^[7] ; Seelaender, Marilia ^{[1, 5]}

Affiliation

^[1] Univ Sao Paulo, Canc Metab Res Grp, Inst Biomed Sci, Sao Paulo - Brazil

^[2] NCI, Lab Integrat Canc Immunol, Ctr Canc Res, NIH, Bethesda, MD 20892 - USA

^[3] Univ Fed Piaui, Dept Phys Educ, Teresina - Brazil

^[4] Univ Hosp Univ Sao Paulo, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Med Sch FMUSP, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Dept Cell & Dev Biol, Inst Biomed Sci, Sao Paulo - Brazil

^[7] Sapienza Univ Rome, Dept Clin Med, Rome - Italy

• Document type: Journal article
• Source: FRONTIERS IN NUTRITION; v. 7, JAN 31 2020.
• Web of Science Citations: 0

Abstract

Cancer cachexia affects about 80% of advanced cancer patients, it is linked to poor prognosis and to date, there is no efficient treatment or cure. The syndrome leads to progressive involuntary loss of muscle and fat mass induced by systemic inflammatory processes. The role of the white adipose tissue (WAT) in the onset and manifestation of cancer cachexia gained importance during the last decade. WAT wasting is not only characterized by increased lipolysis and release of free fatty acids (FFA), but in addition, owing to its high capacity to produce a variety of inflammatory factors. The aim of this study was to characterize plasma lipid profile of cachectic patients and to correlate the FA composition with circulating inflammatory markers; finally, we sought to establish whether the fatty acids released by adipocytes trigger and/or contribute to local and systemic inflammation in cachexia. The study selected 65 patients further divided into 3 groups: control (N); weight stable cancer (WSC); and cachectic cancer (CC). The plasma FA profile was significantly different among the groups and was positively correlated with pro-inflammatory cytokines expression in the CC patients. Therefore, we propose that saturated to unsaturated FFA ratio may serve as a means of detecting cachexia. (AU)

• FAPESP's process: 13/17178-7 - Adipose tissue heterogeneity in cachexia: lipid profile in subcutaneous and visceral tissue of cancer patients
• Grantee: Daniela Mendes dos Reis Riccardi
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 12/50079-0 - Systemic inflammation in cachectic cancer patients: mechanisms and therapeutical strategies, a translational medicine approach
• Grantee: Marilia Cerqueira Leite Seelaender
• Support Opportunities: Research Projects - Thematic Grants