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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis of amphiphilic pullulan-graft-poly(epsilon-caprolactone) via click chemistry

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Carvalho, Layde T. [1] ; Moraes, Rodolfo M. [1] ; Alves, Gizelda M. [1] ; Lacerda, Talita M. [2] ; Santos, Julio C. [2] ; Santos, Amilton M. [1] ; Medeiros, Simone F. [1]
Total Authors: 7
[1] Univ Sao Paulo, EEL, Dept Chem Engn, Engn Sch Lorena, Estr Municipal Campinho S-N, BR-1602810 Lorena, SP - Brazil
[2] Univ Sao Paulo, Engn Sch Lorena, Dept Biotechnol, Lorena, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: International Journal of Biological Macromolecules; v. 145, p. 701-711, FEB 15 2020.
Web of Science Citations: 0

Chemical modification of natural polymers has been commonly employed for the development of new bio-based materials, aiming at adjusting specific properties such as solubility, biodegradability, thermal stability and mechanical behavior. Among all natural polymers, polysaccharides are promising materials, in which biodegradability, processability and bioreactivity make them suitable for biomedical applications. In this context, this work describes the synthesis and characterization of a novel amphiphilic pullulan-g-poly(epsilon-caprolactone) (Pull-g-PCL) graft copolymer. In a first step, pullulan was chemically modified with 2-bromopropionyl bromide to obtain bromo-functionalized pullulan (PullBr). Then, this precursor was modified with sodium azide, leading to azide pullulan (PullN(3)). In parallel, propargyl-terminated poly(epsilon-caprolactone) was prepared via ring-opening polymerization (ROP). These preliminary steps involved the synthesis of azide and alkyne compounds, capable of being linked together via alkyne-azide cycloaddition reaction catalyzed by copper (Cu (I)), which leads to Pull-g-PCL. The chemical structures of the polymers were assessed by Proton Nuclear Magnetic Resonance (H-1 NMR) and Fourier Transform Infrared (FTIR). (C) 2019 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 19/04269-0 - Evaluation of novel polymer nanoparticles as potential carriers for simultaneous release of a photosensitising agent and an active chemotherapeutic agent
Grantee:Simone de Fátima Medeiros Sampaio
Support Opportunities: Regular Research Grants