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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The interplay between host haemostatic systems and Leptospira spp. infections

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Author(s):
Vieira, Monica L. [1] ; Herwald, Heiko [2] ; Nascimento, Ana Lucia T. O. [3]
Total Authors: 3
Affiliation:
[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, Belo Horizonte, MG - Brazil
[2] Lund Univ, Dept Clin Sci, Div Infect Med, Lund - Sweden
[3] Butantan Inst, Lab Desenvolvimento Vacinas, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: CRITICAL REVIEWS IN MICROBIOLOGY; v. 46, n. 2 MAR 2020.
Web of Science Citations: 0
Abstract

Hemostasis is a defence mechanism that protects the integrity of the vascular system and is comprised of the coagulation cascade, fibrinolysis, platelet aggregation, and vascular endothelium. Besides the primary function in preserving the vascular integrity, the haemostatic system cooperates with immune and inflammatory processes to eliminate invading pathogens during microbial infections. Under pathological manifestations, hemostasis must therefore interact in a coordinated manner with inflammatory responses and immune reactions. Several pathogens can modulate these host-derived countermeasures by specifically targeting certain haemostatic components for their own benefit. Thus, the ability to modulate host defence systems has to be considered as an essential bacterial virulence mechanism. Complications that bacterial pathogens can induce are therefore often the consequence of evoked host responses. A comprehensive understanding of the molecular mechanisms triggered in infectious processes may help to develop prophylactic methods and novel therapies for the patients suffering from a particular infectious disease. This review aims to provide a critical updated compiling of recent studies on how the pathogenic Leptospira can interact with and manipulate the host haemostatic systems and the consequences for leptospirosis pathogenesis. (AU)

FAPESP's process: 17/00236-5 - Platelets at the interface of immunity, inflammation and hemostasis modulation in leptospirosis
Grantee:Mônica Larucci Vieira
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 14/50981-0 - Search for surface proteins among the genome sequences of Leptospira interrogans: functional and immunological characterization to understanding mechanisms involved in the bacterial pathogenesis
Grantee:Ana Lucia Tabet Oller do Nascimento
Support Opportunities: Research Projects - Thematic Grants