| Full text | |
| Author(s): |
Ribeiro, Alessandra C. R.
[1]
;
Lyra, Arthur
[2]
;
Bonfitto, Alexandre J.
[3]
;
Tostes Filho, V, Gilmar
;
Zanesco, Leonardo
[4]
;
Fleury, Eduardo F. C.
[1]
;
Ferreira, Aleksandro B.
[2]
;
Longui, Carlos A.
[2]
;
Monte, Osmar
[2]
;
Kochi, Cristiane
[2]
Total Authors: 10
|
| Affiliation: | [1] Santa Casa Sao Paulo Sch Med Sci, Dept Radiol, Sao Paulo, SP - Brazil
[2] Santa Casa Sao Paulo Sch Med Sci, Pediat Endocrinol Unit, 112 Dr Cesario Mota Jr St, BR-01238010 Sao Paulo, SP - Brazil
[3] Santa Casa Sao Paulo Sch Med Sci, Sao Paulo, SP - Brazil
[4] Tostes Filho, Gilmar, V, Santa Casa Sao Paulo Sch Med Sci, Sao Paulo, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM; v. 33, n. 3, p. 339-345, MAR 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: The intima-media thickness of the carotid artery (cIMT) and endothelial dysfunction are associated with cardiovascular (CV) disease. Objectives: To evaluate the correlation between cIMT, brachial intraluminal diameter and flow-mediated vasodilation on the reactive hyperemia phase in adolescents with obesity with predictors of CV risk. Methods: Seventy-three pubertal patients with overweight or obesity were evaluated (45 girls) with a mean (standard deviation {[}SD]) age of 12.9 (2.5) years. Patients underwent anthropometric measurements and had the lipid profile, oral glucose tolerance test (oGTT) and serum intercellular adhesion molecule-1 (sICAM-1) levels analyzed. The ratios of the waist circumference (WC)/height (WHtR) and triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C), homeostatic model assessment of insulin resistance (HOMA-IR), the Matsuda index and insulin area under the curve (AUC) were calculated. All patients were evaluated for cIMT and arterial blood flow velocity of the brachial artery. Results: 75.3% of the patients had high cIMT values. We found a positive correlation between WHtR and cIMT (r = 0.233; p = 0.050). There was a positive correlation between sICAM-1 and insulin AUC (r = 0.323; p = 0.012) and WHtR (r = 0.258; p = 0.047). Patients with abnormal arterial dilation had higher sICAM-1 values (p = 0.02) despite having smaller WHtR (p = 0.046). Conclusions: These adolescents with obesity had high cIMT values. Insulin resistance was associated with sICAM-1. Endothelial dysfunction was positively correlated with sICAM-1. There is no consensus about what the best laboratorial approach to evaluate insulin resistance in adolescents is, and the cutoff values of each method are arbitrary. So, as we saw earlier, the association between anthropometric data (WHtR) and ultrasound findings could be useful to evaluate the CV risk of these adolescents with obesity, because of its practical, direct and lowcost value. (AU) | |
| FAPESP's process: | 13/23539-2 - Assessment of cardiovascular risk markers in obese adolescents |
| Grantee: | Cristiane Kochi |
| Support Opportunities: | Regular Research Grants |