Plasma levels of matrix metalloproteinase-9 are elevated in individuals with hypertensive crisis

Author(s)

Valente, Flavia Mariana ^[1] ; de Andrade, Days Oliveira ^[1] ; Cosenso-Martin, Luciana Neves ^[1] ; Cesarino, Claudia Bernardi ^[1] ; Guimaraes, Sergio Mussi ^[1] ; Guimaraes, Victor Beneditti ^[2] ; Lacchini, Riccardo ^[3] ; Tanus-Santos, Jose Eduardo ^[4] ; Yugar-Toledo, Juan Carlos ^[1] ; Vilela-Martin, Jose Fernando ^[1]

Affiliation

^[1] State Med Sch Sao Jose do Rio Preto FAMERP, Internal Med Dept, Hypertens Clin, Ave Brig Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[2] Med Sch FACERES, Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Dept Psychiat Nursing & Human Sci, R Prof Hello Lourenco, BR-3900 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ave Bandeirantes, BR-3900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: BMC CARDIOVASCULAR DISORDERS; v. 20, n. 1 MAR 12 2020.
• Web of Science Citations: 0

Abstract

Background Matrix metalloproteinase-9 (MMP-9) participates in the degradation of components of the extracellular matrix and it is involved in vascular remodeling and vasomotor changes. The aim of this study was to investigate the plasma levels of MMP-9 in acute vascular alterations due to hypertensive crisis. Methods This cross-sectional study was performed in 40 normotensive (NT) and 58 controlled hypertensive subjects (CHyp) followed up in outpatient clinic. Moreover, 57 patients with hypertensive emergency (HypEmerg) and 43 in hypertensive urgency (HypUrg), seen in emergency department, were also included. Hypertensive crisis was divided into HypEmerg, which was characterized by levels of systolic blood pressure (BP) >= 180 mmHg and/or diastolic BP >= 120 mmHg complicated with target-organ damage (TOD), and HypUrg, defined by BP elevation without TOD. Univariate and multivariate regression analysis was performed to identify the influence of independent variables on MMP-9 levels. A p-value < 0.05 was considered statistically significant. Results The mean age was 43.5 years in the NT group (11 men); 57.7 years in the CHyp group (29 men); 59.4 years in the HypUrg group (21 men) and 62.4 years in the HypEmerg group (31 men). The age was statistically different in the NT group compared to other 3 groups. The mean BP was 116.5 +/- 13.9/72.4 +/- 10.6 mmHg for NT, 123.2 +/- 12.6/79 +/- 9.2 for CHyp, 194.1 +/- 24.3/121.4 +/- 17.3 for HypUrg and 191.6 +/- 34.3/121.7 +/- 18.8 mmHg for HypEmerg, respectively (p-value< 0.0001 between groups). MMP-9 levels were statistically different between the HypEmerg (2.31 +/- 0.2 ng/mL) and HypUrg groups (2.17 +/- 0.3 ng/mL) compared to the NT (1.94 +/- 0.3 ng/mL) (p-value < 0.01 and p-value < 0.05, respectively) and CHyp groups (1.92 +/- 0.2 ng/mL) (p-value < 0.01). Uric acid was the only independent variable for predicting MMP-9 levels (p-value = 0.001). Conclusion MMP-9 concentrations are significantly higher in the hypertensive crisis groups (urgency and emergency) compared to the control groups. Therefore, MMP-9 may be a biomarker or mediator of pathophysiologic pathways in cases of acute elevations of blood pressure. (AU)

• FAPESP's process: 13/09868-3 - Proinflammatory cytokines, C-reactive protein and participation of renin-angiotensin system in patients with hypertensive crisis
• Grantee: José Fernando Vilela Martin
• Support Opportunities: Regular Research Grants