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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fabrication of random and aligned electrospun nanofibers containing graphene oxide for skeletal muscle cells scaffold

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Uehara, Thiers M. [1] ; Paino, Ieda M. M. [1] ; Santos, Fabricio A. [1] ; Scagion, Vanessa P. [2, 3] ; Correa, Daniel S. [2, 3] ; Zucolotto, Valtencir [1]
Total Authors: 6
[1] Univ Sao Paulo, Phys Inst Sao Carlos, Nanomed & Nanotoxicol Grp, BR-369 Sao Carlos, SP - Brazil
[2] Embrapa Instrumentacao, LNNA, BR-13560970 Sao Carlos - Brazil
[3] Fed Univ Sao Carlos UFSCar, PPGQ, Dept Chem, Ctr Exact Sci & Technol, Sao Carlos - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 0

Graphene oxide (GO)-based materials have been explored in biomedical applications as active engineered materials for diagnosis and therapy. Although a large number of studies have been carried out in the last years, aspects involving the orientation and elongation of cells on GO immobilized on polymeric nanofibers are still scarce. We investigated the interactions between skeletal muscle cells and GO immobilized on random and aligned electrospun nanofibers of poly(caprolactone) (PCL), a biocompatible and biodegradable polymer. Oxygen plasma was employed to modify the nanofiber polymer surface to enhance the interactions between the PCL fibers and GO. Scanning electron microscopy and confocal microscopy revealed the morphology and orientation of skeletal muscle cells (C2C12 cells) on random and aligned GO/PCL nanofibers. The approach employed here is useful to investigate the interaction of skeletal muscle cells with biocompatible polymer nanofibers modified with GO intended for cell scaffolds and tissue engineering. (AU)

FAPESP's process: 13/21292-0 - Interaction study of graphene oxide with cell membrane models and with stem cells
Grantee:Thiers Massami Uehara
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/12174-4 - Development of hybrid polymer nanofibers for agricultural applications
Grantee:Daniel Souza Corrêa
Support Opportunities: Regular Research Grants