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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Significant association of SYNTAX score on release of cardiac biomarkers in uncomplicated post-revascularization procedures among patients with stable multivessel disease MASS-V Study group

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Author(s):
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Cardoso de Azevedo, Diogo Freitas [1] ; Hueb, Whady [1] ; Lima, Eduardo Gomes [1] ; Rezende, Paulo Cury [1] ; Linhares Filho, Jaime Paula Pessoa [1] ; de Carvalho, Guilherme Fernandes [1] ; Martins, Eduardo Bello [1] ; Nomura, Cesar Higa [1] ; Cassaro Strunz, Celia Maria [1] ; Serrano Junior, Carlos Vicente [1] ; Franchini Ramires, Jose Antonio [1] ; Kalil Filho, Roberto [1]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Fac Med, HCFMUSP, Hosp Clin, Inst Coracao InCor, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: MEDICINE; v. 99, n. 8 FEB 2020.
Web of Science Citations: 0
Abstract

This study investigated the relationship between angiographic complexities of coronary artery disease (CAD) assessed by SYNTAX Score synergy between percutaneous coronary intervention with taxus and cardiac surgery score (SYNTAX Score) and cardiac biomarker elevation after revascularization procedures. This is a post-hoc analysis of the medicine, angioplasty or surgery study V study of patients with stable CAD. High-sensitivity troponin 1 (hs-TnI) and creatinine kinase-muscle/brain (CK-MB) were assessed before and after cardiovascular procedures. Baselines SYNTAX Scores (SXScores) were calculated by blinded investigators to patient characteristics. Of the 202 patients studied, the mean SXScore was 21.25 +/- 9.24; 40.10 +/- 7.09 in the high SXScore group and 19.06 +/- 6.61 in low/mid SXscore group (P < .0001). Positive correlations existed between SXScore and median peaks after procedural hs-TnI (r = 0.18, P = .009) and CK-MB (r = 0.24, P = .001) levels. In patients with high SXScores (>= 33), the median peaks of post-procedural hs-TnI (P = .034)and CK-MB (P = .004) levels were higher than in low/mid SXScore group (<33).The release of hs-TnI at 6 (P = .002), 12 (P = .008), and 24 hours (P = .039) was higher in high SXScore group than in low/mid SXscore group (<33) as was the release of CK-MB at 6 (P < .0001), 12 (P < .0001), 24 (P = .001), 36 (P = .007), 48 (P = .008), and 72 hours (P = .023). After multivariable analysis, high SXScore was a significant independent predictor of release of CK-MB and hs-TnI peaks higher than the median. The increase in release of cardiac biomarkers was significantly associated with the extent of atherosclerosis identified by the SYNTAX Score. (AU)

FAPESP's process: 11/20876-2 - Increase in biomarkers of myocardial necrosis after surgical or percutaneous revascularization in the absence of demonstrated myocardial infarction
Grantee:Whady Armindo Hueb
Support Opportunities: Regular Research Grants