Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous

Full text
Author(s):
Silva-Filho, Joao Luiz [1, 2] ; Lacerda, Marcus V. G. [3, 4] ; Recker, Mario [5] ; Wassmer, Samuel C. [6] ; Marti, Matthias [2] ; Costa, Fabio T. M. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Lab Doencas Trop, Prof Luiz Jacintho da Silva Inst Biol, Campinas - Brazil
[2] Univ Glasgow, Wellcome Ctr Integrat Parasitol, Inst Infect Immun & Inflammat, Glasgow, Lanark - Scotland
[3] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas - Brazil
[4] Fiocruz Amazonia, Inst Leonidas & Maria Deane, Manaus, Amazonas - Brazil
[5] Univ Exeter, Ctr Math & Environm, Penryn Campus, Penryn - England
[6] London Sch Hyg & Trop Med, Dept Infect Biol, Fac Infect & Trop Dis, London - England
Total Affiliations: 6
Document type: Review article
Source: Trends in Parasitology; v. 36, n. 5, p. 447-458, MAY 2020.
Web of Science Citations: 2
Abstract

Estimation of Plasmodium vivax biomass based on circulating biomarkers indicates the existence of a predominant biomass outside of the circulation that is not captured by peripheral parasitemia, in particular in patients with complicated outcomes. A series of recent studies have suggested that the hematopoietic niche of the bone marrow (BM) is a major reservoir for parasite replication and the development of transmission stages. However, significant knowledge gaps remain in our understanding of host-parasite interactions, pathophysiology, and the implications for treatment and diagnosis of such a reservoir. Here, we discuss the current status of this emerging research field in the context of P. vivax. (AU)

FAPESP's process: 19/01578-2 - Host-parasite interactions in the bone marrow: a key role in Malaria pathogenesis
Grantee:João Luiz da Silva Filho
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 16/12855-9 - Mechanism of action of lipoxin in the protection against experimental cerebral malaria
Grantee:João Luiz da Silva Filho
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/18611-7 - Development of new tools for search and validation of molecular targets for therapy against Plasmodium vivax
Grantee:Fabio Trindade Maranhão Costa
Support Opportunities: Research Projects - Thematic Grants