| Full text | |
| Author(s): |
Stringasci, Mirian Denise
[1]
;
Salvio, Ana Gabriela
[2]
;
Moriyama, Lilian Tan
[1]
;
Vollet-Filho, Jose Dirceu
[1]
;
Fortunato, Thereza Cury
[1]
;
Bagnato, Vanderlei Salvador
[1]
;
Kurachi, Cristina
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil
[2] Amaral Carvalho Fdn, Skin Dept, Jau - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Photodiagnosis and Photodynamic Therapy; v. 29, MAR 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
The changes in tissue temperature of basal cell carcinoma lesions were investigated during photodynamic therapy in order to better understand the effects and mechanisms of PDT in tissue. In this study, the monitoring of 40 lesions of basal cell carcinoma was performed during photodynamic therapy. The lesion region becomes thermally evident throughout the procedure, and there is an improved contrast of the lesion edges after the end of the irradiation. The comparison between thermal and fluorescence images showed a correlation between the PpIX evidenced through widefield fluorescence and the temperature gradient of the thermal images after the procedure, indicating that thermography is a potential diagnostic tool to evaluate the selective response of PDT. A model was created to calculate the amount of light energy converted to heat, tissue damage, and other energy transfer processes involved in the PDT. Using this model, it was shown that most of the energy conversion was in photodynamic action (48.7% and 48.3%, in first and second session, respectively), followed by the energy ratio attributable to blood perfusion (37.2%). This is evidence that photodynamic therapy does not generate a significant thermal component, an important aspect of the study of its mechanisms. (AU) | |
| FAPESP's process: | 13/07276-1 - CEPOF - Optics and Photonic Research Center |
| Grantee: | Vanderlei Salvador Bagnato |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences |
| Grantee: | Vanderlei Salvador Bagnato |
| Support Opportunities: | Research Projects - Thematic Grants |