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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of the biological potential of ruthenium(II) complexes with cinnamic acid

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Author(s):
Graminha, Angelica E. [1, 2] ; Honorato, Joao [1] ; Dulcey, Liany Luna [2] ; Godoy, Luani Rezende [2] ; Barbosa, Marilia F. [3] ; Cominetti, Marcia R. [2] ; Menezes, Antonio C. [4] ; Batista, Alzir A. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Gerontol, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Fed Alfenas, Inst Quim, BR-37130000 Alfenas, MG - Brazil
[4] Univ Estadual Goias, Ctr Ciencias Exatas & Tecnol, BR-75132903 Anapolis, Go - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Inorganic Biochemistry; v. 206, MAY 2020.
Web of Science Citations: 6
Abstract

In this work, we present the synthesis and characterization of five new ruthenium compounds with general formula {[}Ru(L)(dppb)(bipy)]PF6, where L = cinnamic acid derivatives, dppb = 1,4-bis(diphenylphosphino) butane and bipy = 2, 2'-bipyridine. The cytotoxicity of the complexes was evaluated against human breast tumor cells from the lines MCF-7, MDA-MB-231 and in human (MCF-10A) or mouse (L929) non-tumor cells. Complexes Ru(L-4)(dppb)(bipy)]PF6 (4) (L-4 = 4-hydroxycinnamic acid) and {[}Ru(L-5)(dppb)(bipy)]PF6 (5) (L-5 = 3,4-dihydroxycinnamic acid) were the most selective, presenting the highest values of selectivity indexes besides inhibited some processes related to tumor progression in vitro, such as invasion, migration, and adhesion in the MDA-MB-231 cell line. In addition, the complexes 4 and 5 were able to interact with Bovine Serum Albumin (BSA) and complex 5 showed antioxidant activity. (AU)

FAPESP's process: 14/19632-0 - New ruthenium complexes with bioactive ligands: investigation of the mechanismo of action
Grantee:Angelica Ellen Graminha
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/24940-8 - EFFECTIVENESS OF STRUCTURAL CHANGES IN [10]-GINGEROL MOLECULE IN COMBINATION WITH THE CHEMOTHERAPEUTIC DOXORUBICIN FOR THE TREATMENT OF BREAST CANCER: IN VITRO AND IN VIVO STUDIES. ABSTRACT
Grantee:Márcia Regina Cominetti
Support Opportunities: Regular Research Grants
FAPESP's process: 16/16312-0 - CYTOTOXICITY AND MECHANISM OF ACTION OF RUTHENIUM COMPLEXES CONTAINING NATURAL PRODUCTS OR DERIVATIVES
Grantee:Alzir Azevedo Batista
Support Opportunities: Regular Research Grants