STIM calcium sensing and conformational change

Author(s)

Gudlur, Aparna ^[1] ; Zeraik, Ana Eliza ^{[2, 1]} ; Hirve, Nupura ^[1] ; Hogan, Patrick G. ^{[3, 4, 1]}

Affiliation

^[1] La Jolla Inst Immunol, Div Signaling & Gene Express, La Jolla, CA 92037 - USA

^[2] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil

^[3] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 - USA

^[4] Univ Calif San Diego, Program Immunol, La Jolla, CA 92037 - USA

• Document type: Journal article
• Source: JOURNAL OF PHYSIOLOGY-LONDON; v. 598, n. 9, SI, p. 1695-1705, MAY 2020.
• Web of Science Citations: 1

Abstract

The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. ORAI1 is a calcium channel in the plasma membrane (PM). In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Recent work, reviewed here, has offered detailed insight into the process of sensing and communicating ER calcium-store depletion, and particularly into the STIM1 conformational change that is the basis for communication between the ER and the PM. (AU)

• FAPESP's process: 16/12505-8 - Characterization of the calcium release-activated (CRAC) channel in the human pathogen Schistosoma mansoni through the study of its components STIM and ORAI proteins
• Grantee: Ana Eliza Zeraik
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor