Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

STIM calcium sensing and conformational change

Full text
Author(s):
Gudlur, Aparna [1] ; Zeraik, Ana Eliza [2, 1] ; Hirve, Nupura [1] ; Hogan, Patrick G. [3, 4, 1]
Total Authors: 4
Affiliation:
[1] La Jolla Inst Immunol, Div Signaling & Gene Express, La Jolla, CA 92037 - USA
[2] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil
[3] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 - USA
[4] Univ Calif San Diego, Program Immunol, La Jolla, CA 92037 - USA
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF PHYSIOLOGY-LONDON; v. 598, n. 9, SI, p. 1695-1705, MAY 2020.
Web of Science Citations: 1
Abstract

The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. ORAI1 is a calcium channel in the plasma membrane (PM). In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Recent work, reviewed here, has offered detailed insight into the process of sensing and communicating ER calcium-store depletion, and particularly into the STIM1 conformational change that is the basis for communication between the ER and the PM. (AU)

FAPESP's process: 16/12505-8 - Characterization of the calcium release-activated (CRAC) channel in the human pathogen Schistosoma mansoni through the study of its components STIM and ORAI proteins
Grantee:Ana Eliza Zeraik
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor