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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer

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Author(s):
Vulczak, Anderson [1, 2] ; Souza, Anderson de Oliveira [1] ; Ferrari, Gustavo Duarte [1] ; Caleiro Seixas Azzolini, Ana Elisa [1] ; Pereira-da-Silva, Gabriela [2] ; Alberici, Luciane Carla [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Nurse Ribeirao Preto, Dept Maternal & Child Nursing & Publ Hlth, BR-14040902 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CELLS; v. 9, n. 3 MAR 2020.
Web of Science Citations: 0
Abstract

Triple-negative breast cancer (TNBC) stands out for its aggressiveness and accelerated rate of proliferation. Evidence shows that exercise may exert antitumorigenic effects, but the biochemical mechanisms underlying them remain unclear. Our objective was to evaluate the ability of exercise to modulate tumor growth and energy metabolism in an experimental TNBC model. Female BALB/c mice were sedentary or trained for 12 weeks and inoculated with 1 x 10(4) 4T1 cells in the eighth week. Analyzes of macronutrient oxidation, mitochondrial respiration, and expression of genes related to cell metabolism were performed. The results showed that the trained group had a smaller tumor mass and the mitochondria in the tumors presented lower respiratory rates in the state of maximum electron transport capacity. Additionally, the tumors of the exercised group showed a higher expression of genes related to tumor suppressors, while the genes linked with cellular growth were similar between groups. Furthermore, the training modulated the corporal macronutrient oxidation to almost exclusive carbohydrate oxidation, while the sedentary condition metabolized both carbohydrate and lipids. Therefore, the exercise reduced tumor growth, with an impact on mitochondrial and macronutrient metabolism. Our results shed light on the understanding of the antitumorigenic effects of physical exercise, particularly regarding the metabolic transformations in TNBC. (AU)

FAPESP's process: 16/23509-4 - Identification of neuroprotective myokines released by human skeletal muscle at low and high intensity contractions: role of mitochondrial bioenergetics and oxidative stress
Grantee:Luciane Carla Alberici
Support Opportunities: Regular Research Grants