Predictors of asynchronies during assisted ventilation and its impact on clinical outcomes: The EPISYNC cohort study

Author(s)

de Araujo Sousa, Mayson Laercio ^{[1, 2]} ; Magrans, Rudys ^{[3, 4]} ; Hayashi, Fatima K. ^{[1, 2]} ; Blanch, Lluis ^{[3, 4]} ; Kacmarek, Robert M. ^{[5, 6]} ; Ferreira, Juliana C. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Pneumol, Inst Coracao, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Serv Fisioterapia, Inst Coracao, Sao Paulo, SP - Brazil

^[3] Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli I3PT, Hosp Univ Parc Tauli, Crit Care Ctr, Sabadell - Spain

^[4] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid - Spain

^[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Resp Care, Boston, MA 02115 - USA

^[6] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesiol, Boston, MA 02115 - USA

• Document type: Journal article
• Source: JOURNAL OF CRITICAL CARE; v. 57, p. 30-35, JUN 2020.
• Web of Science Citations: 1

Abstract

Purpose: To investigate if respiratory mechanics and other baseline characteristics are predictors of patient-ventilator asynchrony and to evaluate the relationship between asynchrony during assisted ventilation and clinical outcomes. Methods: We performed a prospective cohort study in patients under mechanical ventilation (MV). Baseline measurements included severity of illness and respiratory mechanics. The primary outcome was the Asynchrony Index (AI), defined as the number of asynchronous events divided by the number of ventilator cycles and wasted efforts. We recorded ventilator waveforms throughout the entire period of MV. Results: We analyzed 11,881 h of MV from 103 subjects. Median AI during the entire period of MV was 5.1% (IQR:2.6-8.7). Intrinsic PEEP was associated with AI (OR:1.72, 95%CI:1.1-2.68), but static compliance and airway resistance were not. Simplified Acute Physiology Score 3 (OR:1.03, 95%CI:1-1.06) was also associated with AI. Median AI was higher during assisted (5.4%, IQR:2.9-9.1) than controlled (2%, IQR:0.6-4.9) ventilation, and 22% of subjects had high incidence of asynchrony (AI=10%). Subjects with AI=10% had more extubation failure (33%) than patients with AIb10% (6%), p =.01. Conclusions: Predictors of high incidence of asynchrony were severity of illness and intrinsic PEEP. High incidence of asynchrony was associated with extubation failure, but not mortality. Trial registration: ClinicalTrials.gov, NCT02687802 (c) 2020 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 15/19122-4 - Relationship between respiratory mechanics and patient-ventilator asynchrony index in patients with invasive mechanical ventilation
• Grantee: Juliana Carvalho Ferreira
• Support Opportunities: Regular Research Grants