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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytoprotective and anti-apoptotic action of HSP70 stress protein in Oreochromis niloticus exposed to residual dilutions of insecticides with fipronil and ethiprole

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Author(s):
Guedes, Thays de Andrade [1] ; Moreira-de-Sousa, Cristina [1] ; Lima, Hellen Maria Soares [1] ; Grella, Tatiane Caroline [1] ; Socolowski, Priscila Cintra [1] ; Fontanetti, Carmem Silvia [1]
Total Authors: 6
Affiliation:
[1] UNESP Sao Paulo State Univ, Dept Biol, IB Inst Biociencias, Ave 24-A, 1515, BR-13506900 Rio Claro, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMIN; v. 55, n. 8 MAY 2020.
Web of Science Citations: 2
Abstract

The objective of this research was to investigate the potential damage caused by the residual concentrations of the insecticides Regent (R) WS 800 and Curbix (R) SC 200, containing fipronil and ethiprole, respectively as active ingredients, on the liver of Oreochromis niloticus. The analyses of HSP70 shock protein labelling and cell death process by TUNEL method were performed in order to measure the effects of the exposure of cell repair system of fish to both insecticides. Statistical analyses showed no significant molecular damage to the hepatic tissue of animals. Nevertheless, variations in HSP70 and DNA fragmentation levels, endpoint of cell repair system response and cellular death, respectively, were observed in several groups. These results indicate that the cell repair machinery was efficient when in contact with residual concentrations of insecticides. However, the DNA fragmentation detected by the TUNEL method suggests that even in face of the cytoprotective action of the HSP70 protein, there are damages that become irreparable. To finish, it is worth mentioning that given the results obtained from residual concentrations, use in the field should be with caution. (AU)

FAPESP's process: 12/50197-2 - Action of products used in cultivation of sugar cane on non-target organisms
Grantee:Carmem Silvia Fontanetti Christofoletti
Support Opportunities: Program for Research on Bioenergy (BIOEN) - Thematic Grants