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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of vitamin C and E on oxidative stress and antioxidant system in the salivary glands of STZ-induced diabetic rats

Full text
Author(s):
Ibuki, Flavia Kazue [1] ; Bergamaschi, Cassia T. [2] ; Pedrosa, Marlus da Silva [1] ; Nogueira, Fernando Neves [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Odontol, Dept Biomat & Oral Biol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 116, AUG 2020.
Web of Science Citations: 1
Abstract

Objective: We examined the effects of vitamin C and E supplementation in the prevention of oxidative stress in the salivary glands of STZ-induced diabetic rats. Design: Forty-eight male Wistar rats were divided into six groups (n = 8 in each): control (C), control supplemented with vitamin C (Cvc) and E (Cve), diabetic (D), and diabetic supplemented with vitamin C (Dvc) and E (Dve). Vitamin C (150 mg/kg) and E (300 mg/kg) were daily administered for 21 days. Serum ascorbic acid and alpha-tocopherol levels were quantified. Glandular levels of hydrogen peroxide (H2O2), superoxide anion (O-2(-)), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), malondialdehyde (MDA) and the total antioxidant status (TAS) were estimated. Results: Vitamin C and E levels were reduced in D group. Vitamin C decreased the levels of O-2(-) in the salivary gland of diabetic rats. Vitamin E increased the concentration of O-2(-) in PA gland of diabetic animals. In the SM gland of the diabetic group, MDA, SOD, GPx and TAS increased. Dve presented reduced SOD activity and increased GR, GPx, and MDA. Dve increased GPx, Gr and TAS levels. In the PA gland, MDA, SOD, CAT, GPx, GR, and TAS were similar in C and D. TAS, SOD, CAT, GPx, and GR increased in Dvc. Vitamin E supplementation resulted in increased MDA and CAT levels and reduced SOD activity. Conclusion: In the SM glands of the diabetic rats, vitamin C supplementation improved the antioxidant system, while vitamin E acted as pro-oxidant. (AU)

FAPESP's process: 13/18609-1 - Oxidative damage in salivary glands of rats in diabetes and chronic renal failure and possible benefits of supplementation of vitamins C and E
Grantee:Fernando Neves Nogueira
Support Opportunities: Regular Research Grants