Exploring response inhibition and error monitoring in obsessive-compulsive disorder

Author(s):Show less -

Silveira, Vitor Portella ^{[1, 2]} ; Frydman, Ilana ^{[3, 4]} ; Fontenelle, Leonardo F. ^{[3, 5, 6]} ; Mattos, Paulo ^[6] ; de Oliveira-Souza, Ricardo ^[6] ; Moll, Jorge ^[6] ; Hoexter, Marcelo Queiroz ^{[1, 2]} ; Miguel, Euripedes Constantino ^{[1, 2]} ; McLaughlin, Nicole C. R. ^{[7, 8]} ; Shephard, Elizabeth ^{[1, 2, 9]} ; Batistuzzo, Marcelo Camargo ^{[1, 2, 10]}

Affiliation

^[1] Univ Sao Paulo, Fac Med FMUSP, Dept Psiquiatria, Sao Paulo, SP - Brazil

^[2] R Dr Ovidio Pires de Campos 785, BR-05403903 Sao Paulo, SP - Brazil

^[3] Univ Fed Rio de Janeiro, Inst Psychiat, Av Venceslau Bras 71, BR-22290140 Rio De Janeiro, RJ - Brazil

^[4] Fluminense Fed Univ, Student Hlth Assistance Div, R Miguel de Frias 9, BR-24220900 Niteroi, RJ - Brazil

^[5] Monash Univ, Turner Inst Brain & Mental Hlth, Wellington Rd, Clayton, Vic 3800 - Australia

^[6] DOr Inst Res & Educ IDOR, R Diniz Cordeiro 30, BR-22281100 Rio De Janeiro, RJ - Brazil

^[7] Brown Univ, Butler Hosp, 345 Blackstone Blvd, Providence, RI 02906 - USA

^[8] Brown Univ, Alpert Med Sch, 345 Blackstone Blvd, Providence, RI 02906 - USA

^[9] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, 16 De Crespigny Pk, London SE5 8AF - England

^[10] Pontifical Catholic Univ Sao Paulo, Humanities & Hlth Sci Sch, Dept Methods & Tech Psychol, R Monte Alegre 984, BR-05014001 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF PSYCHIATRIC RESEARCH; v. 126, p. 26-33, JUL 2020.
• Web of Science Citations: 0

Abstract

Behavioral evidence of impaired response inhibition (RI) and hyperactive error monitoring (EM) in obsessive-compulsive disorder (OCD) is inconsistent. Recent neuroimaging work suggests that EM plays a role in RI impairments in OCD, but this has rarely been investigated using behavioral measures. The aims of this study were to (1) compare RI and EM performance between adults with OCD and non-psychiatric controls (NPC) while investigating possible moderators, and (2) assess whether excessive EM influences RI in OCD. We compared RI and EM performance on the Stop-Signal Task (SST) between 92 adults with OCD and 65 NPC from two Brazilian sites. We used linear regression to investigate which variables (group, age, medication use, clinical symptomatology) influenced performance, as well as to examine possible associations between RI and EM. OCD and NPC did not differ in RI and EM. However, age moderated RI performance in OCD with a medium effect size, reflecting differential effects of age on RI between groups: age was positively associated with RI in OCD but not NPC. Further, OCD severity predicted EM with a medium to large effect size, suggesting that more symptomatic patients showed greater monitoring of their mistakes. Finally, group moderated the relationship between RI and EM with a small effect size. Our findings suggest that demographic factors may influence RI, whereas clinical factors may influence EM. Further, we found preliminary behavioral evidence to indicate that impaired RI and excessive EM are related in OCD. (AU)

• FAPESP's process: 16/05865-8 - Ventromedial prefrontal cortex metabolite levels in obsessive-compulsive patients: a proton magnetic resonance spectroscopy study
• Grantee: Marcelo Camargo Batistuzzo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/21357-9 - Research on neural circuits and biological markers involved in obsessive-compulsive disorder using behavioral paradigms of fear and anxiety
• Grantee: Eurípedes Constantino Miguel Filho
• Support Opportunities: Research Projects - Thematic Grants