Neurophysiological and behavioral measures associated with attentional and inhibitory processes in adult young with ADHD

• Grant number: 19/20757-5
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2020
• End date: September 30, 2022
• Field of knowledge: Humanities - Psychology - Cognitive Psychology
• Principal Investigator: Luiz Renato Rodrigues Carreiro
• Grantee: Luiz Renato Rodrigues Carreiro
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Presbiteriana Mackenzie (UPM). Instituto Presbiteriano Mackenzie. São Paulo , SP, Brazil
• Associated researchers: Alessandra Gotuzo Seabra ; Ana Alexandra Caldas Osório ; Maria Cristina Triguero Veloz Teixeira ; Walter Machado Pinheiro
• Associated scholarship(s): 20/14800-2 - Biological measures recordig during the execution of computerized tests of attention and inhibition., BP.TT

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is characterized by harmful levels of inattention, hyperactivity, and impulsivity and occurs in 2.5% of adults. This project will evaluate young adults with ADHD in computerized tasks for different forms of attention and inhibition, correlating them with self-report scales and physiological measurements (EMG and fNIRS) to identify impairments in specific cognitive domains, as well as electromyographic and functional neuroimaging indicators, that can be used to characterize ADHD endophenotypes. The study will be conducted with two groups: one with ADHD - GClin and one control - CG, with 50 participants between 18 and 28 years each. Initially, participants will perform CPT-3 and respond to ASRS to be allocated to the CG or GClin, with validation by a specialist physician. After that, they will do the computerized inhibition (Stroop / Stop) and spatial (voluntary and automatic) and temporal attention tests. In this phase the data will be collected using electromyographic measurements and recording of brain activity in areas of the prefrontal cortex through fNIRS. After the tests they will complete the impulsivity scales (BIS-11 and UPPS). The analyzes will comprise: (1) ANOVA of the means of TRs and the accuracy (% of errors) of the computerized tests; (2) Pearson correlation analysis between RTs, test accuracy and ASRS scores. In addition, for GClin correlations will include impulsivity scale scores (BIS-11 and UPPS); (3) The number of double activations and subliminal activities (EMG) obtained in the Stroop / Stop test will be submitted to ANOVAs and correlation analyzes with the different scales and (4) The fNIRS analysis will use the oxyhemoglobin signal, which will be analyzed individually. Thus, integration of physiological measurements, scales and tests will ensure integrated understanding of attentional and inhibitory processes impaired in ADHD. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AFONSO JUNIOR, ARMANDO DOS SANTOS; MACHADO-PINHEIRO, WALTER; CALDAS OSORIO, ANA ALEXANDRA; SEABRA, ALESSANDRA GOTUZO; TRIGUERO VELOZ TEIXEIRA, MARIA CRISTINA; NASCIMENTO, JULIA DE ARAUJO; RODRIGUES CARREIRO, LUIZ RENATO. Association between ADHD symptoms and inhibition-related brain activity using functional near-infrared spectroscopy (fNIRS). Neuroscience Letters, v. 792, p. 6-pg., 2023-01-01. (20/14800-2, 19/21773-4, 19/20757-5)

CARREIRO, L. R. R.; PAES, I. T.; SILVA, M. M. M.; SEABRA, A. G.. CLUSTER ANALYSIS OF ATTENTIONAL PERFORMANCE AND BEHAVIORAL EXPRESSIONS IN ADULTS WITH ADHD SYMPTOMS. EUROPEAN PSYCHIATRY, v. 66, p. 1-pg., 2023-03-01. (19/20757-5, 20/14800-2, 19/21773-4)

CARREIRO, L. R. R.; AFONSO JUNIOR, A. A. D. S.; MACHADO-PINHEIRO, W.. Different patterns of frontal and temporoparietal activities related to distinct inhibitory functions in adhd. EUROPEAN PSYCHIATRY, v. 66, p. 1-pg., 2023-03-01. (19/20757-5, 20/14800-2, 19/21773-4)