| Full text | |
| Author(s): |
Alves, Jacqueline Querino
[1]
;
Pernomian, Laena
[2]
;
Silva, Cassia Dias
[1]
;
Gomes, Mayara Santos
[2]
;
de Oliveira, Ana Maria
[2]
;
da Silva, Roberto Santana
[2, 1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Dept Chem, Ave Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto FCFRP, Dept Phys & Chem, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | RSC MEDICINAL CHEMISTRY; v. 11, n. 4, p. 497-510, APR 1 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Catecholamines participate in angiogenesis, an important tumor development process. However, the way catecholamines interact with their receptors has not been completely elucidated, and doubts still remain as to whether these interactions occur between catechol and/or amine sites and particular amino acid residues on the catecholamine receptors. To evaluate how catechol and amine groups contribute to angiogenesis, we immobilized the catechol site through ruthenium ion (Ru) coordination, to obtain species with the general formula {[}Ru(NH3)(4)(catecholamine-R)]Cl. We then assessed the angiogenic activity of the complexes in a chorioallantoic membrane model (CAM) and examined vascular reactivity and calcium mobilization in rat aortas and vascular cells. {[}Ru(NH3)(4)(catecholamine-R)]Cl acted as partial agonists and/or antagonists of their respective receptors and induced calcium mobilization. {[}Ru(NH3)(4)(isoproterenol)](+) {[}Ru(NH3)(4)(noradrenaline)](+), and {[}Ru(NH3)(4)(adrenaline)](+) behaved as antiangiogenic complexes, whereas {[}Ru(NH3)(4)(dopamine)](+) proved to be a proangiogenic complex. In conclusion, catecholamines and {[}Ru(NH3)(4)(catecholamine-R)]Cl can modulate angiogenesis, and catechol group availability can modify the way these complexes impact the vascular tone, suggesting that catecholamines and their receptors interact differently after catecholamine coordination to ruthenium. (AU) | |
| FAPESP's process: | 16/12707-0 - Cytotoxicity and photo-cytotoxicity of new ruthenium-phthalocyanines compounds as nitric oxide and oxygen singlet producers in cancer cell lines. an innovative purpose for metal based drug |
| Grantee: | Roberto Santana da Silva |
| Support Opportunities: | Regular Research Grants |