| Full text | |
| Author(s): |
Harari, Yaniv
[1]
;
Gershon, Lihi
[1, 2]
;
Alonso-Perez, Elisa
[1, 2]
;
Klein, Shir
[1, 2]
;
Berneman, Yael
[1, 2]
;
Choudhari, Karan
[1, 2]
;
Singh, Pragyan
[1, 2]
;
Sau, Soumitra
[3]
;
Liefshitz, Batia
[1, 2]
;
Kupiec, Martin
[1, 2]
Total Authors: 10
|
| Affiliation: | [1] Tel Aviv Univ, Sch Mol Cell Biol & Biotechnol, IL-69978 Ramat Aviv - Israel
[2] Sau, Soumitra, Amity Univ Kolkata, Amity Inst Biotechnol, Kolkata, India.Harari, Yaniv, Tel Aviv Univ, Sch Mol Cell Biol & Biotechnol, IL-69978 Ramat Aviv - Israel
[3] Amity Univ Kolkata, Amity Inst Biotechnol, Kolkata - India
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | FUNGAL BIOLOGY; v. 124, n. 5, p. 311-315, MAY 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Telomeres are structures composed of simple DNA repeats and specific proteins that protect the eukaryotic chromosomal ends from degradation, and facilitate the replication of the genome. They are central to the maintenance of the genome integrity, and play important roles in the development of cancer and in the process of aging in humans. The yeast Saccharomyces cerevisiae has greatly contributed to our understanding of basic telomere biology. Our laboratory has carried out systematic screen for mutants that affect telomere length, and identified similar to 500 genes that, when mutated, affect telomere length. Remarkably, all similar to 500 TLM (Telomere Length Maintenance) genes participate in a very tight homeostatic process, and it is enough to mutate one of them to change the steady-state telomere length. Despite this complex network of balances, it is also possible to change telomere length in yeast by applying several types of external stresses. We summarize our insights about the molecular mechanisms by which genes and environment interact to affect telomere length. (C) 2019 British Mycological Society. Published by Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 18/20571-6 - International Symposium on Fungal Stress - ISFUS |
| Grantee: | Drauzio Eduardo Naretto Rangel |
| Support Opportunities: | Organization Grants - Scientific Meeting |