| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Exeter, MRC Ctr Med Mycol, Dept Biosci, Geoffrey Pope Bldg, Stocker Rd, Exeter EX4 4QD, Devon - England
[2] Pradhan, Arnab, Univ Exeter, MRC Ctr Med Mycol, Dept Biosci, Geoffrey Pope Bldg,Stocker Rd, Exeter EX4 4QD, Devon, England.Brown, Alistair J. P., Univ Exeter, MRC Ctr Med Mycol, Dept Biosci, Geoffrey Pope Bldg, Stocker Rd, Exeter EX4 4QD, Devon - England
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | FUNGAL BIOLOGY; v. 124, n. 5, p. 475-481, MAY 2020. |
| Web of Science Citations: | 2 |
| Abstract | |
The model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, display Core Environmental Responses (CERs) that include the induction of a core set of stress genes in response to diverse environmental stresses. CERs underlie the phenomenon of stress cross-protection, whereby exposure to one type of stress can provide protection against subsequent exposure to a second type of stress. CERs have probably arisen through the accumulation, over evolutionary time, of protective anticipatory responses ({''}adaptive prediction{''}). CERs have been observed in other evolutionarily divergent fungi but, interestingly, not in the pathogenic yeast, Candida albicans. We argue that this is because we have not looked in the right place. In response to specific host inputs, C. albicans does activate anticipatory responses that protect it against impending attack from the immune system. Therefore, we suggest that C. albicans has evolved a CER that reflects the environmental challenges it faces in host niches. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of British Mycological Society. (AU) | |
| FAPESP's process: | 18/20571-6 - International Symposium on Fungal Stress - ISFUS |
| Grantee: | Drauzio Eduardo Naretto Rangel |
| Support Opportunities: | Organization Grants - Scientific Meeting |