| Full text | |
| Author(s): |
Santos, Gabriela F. D.
[1]
;
Anjos, Nicolas S.
[1, 2]
;
Gibeli, Miguel M.
[1, 2]
;
Silva, Guilherme A.
[1, 2]
;
Fernandes, Pamela C. S.
[1, 2]
;
Fiorentino, Everton S. C.
[1, 2]
;
Longo Jr, Luiz S.
Total Authors: 7
|
| Affiliation: | [1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Dept Ciencias Farmaceut, Rua Sao Nicolau 210, BR-09913030 Diadema, SP - Brazil
[2] Longo Jr, Jr., Luiz S., Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Dept Ciencias Farmaceut, Rua Sao Nicolau 210, BR-09913030 Diadema, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 31, n. 7, p. 1434-1444, JUL 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Over the last twenty years, the Groebke-Blackburn-Bienaymé (GBB) reaction has been emerged as a powerful tool to access different nitrogen-based heterocycles as privileged scaffolds in medicinal chemistry. This multicomponent reaction is usually catalyzed by ordinary Brønsted or Lewis acid catalysts. Herein, we present a comparative study on the catalytic efficiencies of different rare earth triflates in GBB reactions under microwave heating, involving 2-aminopyridine or 2-aminothiazole, as aminoazole component, and different aldehydes and aliphatic isocyanides. The use of gadolinium(III) triflate as cheaper alternative catalyst for the most commonly used scandium(III) triflate was acknowledged for the first time, and a library of twenty three imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazoles could be obtained in good to excellent yields. (AU) | |
| FAPESP's process: | 19/01314-5 - Lewis acid immobilization onto polymer-supported ionic liquid phases: a x-ray photoelectron spectroscopy study |
| Grantee: | Luiz Sidney Longo Junior |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 15/11155-0 - 250th ACS National Meeting & Exposition |
| Grantee: | Luiz Sidney Longo Junior |
| Support Opportunities: | Research Grants - Meeting - Abroad |
| FAPESP's process: | 17/06628-2 - Acidic task specific ionic liquids catalyzed Groebke-Blackburn-Bienaymé reaction in the synthesis of imidazo[2,1-b]thiazoles |
| Grantee: | Nicolas Santos dos Anjos |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |