Multispectral autofluorescence dermoscope for skin lesion assessment

Author(s)

Romano, Renan Arnon ^[1] ; Teixeira Rosa, Ramon Gabriel ^{[1, 2]} ; Salvio, Ana Gabriela ^[3] ; Jo, Javier A. ^[4] ; Kurachi, Cristina ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil

^[2] Jo, Javier A., Univ Oklahoma, Sch Elect \& Comp Engn, Norman, OK 73019 USA.Romano, Renan Arnon, Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil

^[3] Amaral Carvalho Hosp, Skin Dept, Jau, SP - Brazil

^[4] Univ Oklahoma, Sch Elect & Comp Engn, Norman, OK 73019 - USA

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 30, JUN 2020.
• Web of Science Citations: 0

Abstract

Basal cell carcinoma (BCC) is the most common type of skin cancer. Diagnosis and edge assessment of BCC lesions are based on clinical and dermoscopy evaluation, which are strongly dependent on the expertise and training of the physician. There is a high rate of underdiagnosis because BCC is frequently confused with certain common benign lesions and is often indistinguishable from the surrounding healthy tissue. In the present study, a multispectral fluorescence lifetime imaging (FLIm) dermoscopy system, designed for imaging and analyzing the autofluorescence emission of skin tissue, was used to image thirty-eight patients with diagnosed nodular BCC (nBCC) lesions, using clinically acceptable levels of excitation light exposure. With this system, skin autofluorescence was imaged simultaneously using three emission bands: 390 +/- 20 nm, 452 +/- 22 nm, and > 496 nm, preferentially targeting collagen, NADH, and FAD autofluorescence, respectively. Statistical classifiers based on FLIm features developed to discriminate BCC from healthy tissue showed promising performance (ROC area-under-the-curve of 0.82). This study demonstrates the feasibility of clinically performing multispectral endogenous FLIm dermoscopy providing baseline results indicating the potential of this technology as an imageguided tool to improve the delineation of nBCC during surgical lesion resection. (AU)

• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Projects - Thematic Grants