| Full text | |
| Author(s): |
Poole, Emma
[1]
;
Neves, Tainan Cerqueira
[2]
;
Oliveira, Martha Trindade
[2]
;
Sinclair, John
[1]
;
da Silva, Maria Cristina Carlan
[2]
Total Authors: 5
|
| Affiliation: | [1] Univ Cambridge, Dept Med, Cambridge - England
[2] Fed Univ ABC UFABC, Ctr Nat & Humanities Sci, Sao Bernardo Do Campo - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 10, JUN 9 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Human Cytomegalovirus (HCMV) can cause a variety of health disorders that can lead to death in immunocompromised individuals and neonates. The HCMV lifecycle comprises both a lytic (productive) and a latent (non-productive) phase. HCMV lytic infection occurs in a wide range of terminally differentiated cell types. HCMV latency has been less well-studied, but one characterized site of latency is in precursor cells of the myeloid lineage. All known viral genes are expressed during a lytic infection and a subset of these are also transcribed during latency. The UL111A gene which encodes the viral IL-10, a homolog of the human IL-10, is one of these genes. During infection, different transcript isoforms of UL111A are generated by alternative splicing. The most studied of the UL111A isoforms are cmvIL-10 (also termed the ``A{''} transcript) and LAcmvIL-10 (also termed the ``B{''} transcript), the latter being a well-characterized latency associated transcript. Both isoforms can downregulate MHC class II, however they differ in a number of other immunomodulatory properties, such as the ability to bind the IL10 receptor and induce signaling through STAT3. There are also a number of other isoforms which have been identified which are expressed by differential splicing during lytic infection termed C, D, E, F, and G, although these have been less extensively studied. HCMV uses the viral IL-10 proteins to manipulate the immune system during lytic and latent phases of infection. In this review, we will discuss the literature on the viral IL-10 transcripts identified to date, their encoded proteins and the structures of these proteins as well as the functional properties of all the different isoforms of viral IL-10. (AU) | |
| FAPESP's process: | 18/19936-0 - Evaluation of the UL111A transcripts expression in HCMV latent infected cells and determination of immunologic properties of the vIL10 proteins in dendritic cells |
| Grantee: | Maria Cristina Carlan da Silva |
| Support Opportunities: | Scholarships abroad - Research |