Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training

Author(s)

Benini, Ricardo ^{[1, 2]} ; Oliveira, Leandro A. ^{[1, 2]} ; Gomes-de-Souza, Lucas ^{[1, 2]} ; Rodrigues, Bruno ^[3] ; Crestani, Carlos C. ^{[1, 2]}

Affiliation

^[1] Joint UFSCar UNESP Grad Program Physiol Sci, BR-13565905 Sao Carlos, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Lab Pharmacol, BR-14800903 Araraquara, SP - Brazil

^[3] Univ Campinas UNICAMP, Fac Phys Educ, Dept Adapted Phys Act, BR-13083851 Campinas, SP - Brazil

• Document type: Journal article
• Source: Journal of Experimental Biology; v. 223, n. 8 APR 2020.
• Web of Science Citations: 0

Abstract

This study evaluated the effect of exposure to either a chronic variable stress (CVS) protocol or social isolation, as well as treadmill exercise training, in the habituation of the cardiovascular response upon repeated exposure to restraint stress in rats. The habituation of the corticosterone response to repeated restraint stress was also evaluated. For this, animals were subjected to either acute or 10 daily sessions of 60 min of restraint stress. CVS and social isolation protocols lasted for 10 consecutive days, whereas treadmill training was performed for 1 h per day, 5 days per week for 8 weeks. We observed that the increase in serum corticosterone was reduced during both the stress and the recovery period of the 10th session of restraint. Habituation of the cardiovascular response was identified in terms of a faster return of heart rate to baseline values during the recovery period of the 10th session of restraint. The increase in blood pressure and the decrease in tail skin temperature were similar at the 1st and 10th session of restraint. Exposure to CVS, social isolation or treadmill exercise training inhibited the habituation of the restraint-evoked tachycardia. Additionally, CVS increased the blood pressure response at the 10th session of restraint, whereas social isolation enhanced both the tachycardia during the first session and the drop in skin temperature at the 10th session of restraint. Taken together, these findings provide new evidence that pathologies evoked by stress might be related to impairment in the habituation process to homotypic stressors. (AU)

• FAPESP's process: 15/05922-9 - Study of the participation of CRF neurotransmission in the bed nucleus of the stria terminalis in cardiovascular changes evoked by stress: interaction with the NMDA receptor/nitric oxide / guanilil cycles / protein kinase g signaling pathway?
• Grantee: Carlos Cesar Crestani
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/19249-0 - Involvement of angiotensinergic neurotransmissions of medial amygdaloid nucleus in control of cardiovascular and anxiogenic responses to stress in rats.
• Grantee: Carlos Cesar Crestani
• Support Opportunities: Regular Research Grants