Are ovarian reserve tests reliable in predicting ovarian response? Results from a prospective, cross-sectional, single-center analysis

Author(s)

Peluso, Carla ^[1] ; de Oliveira, Renato ^[1] ; Laporta, Gabriel Zorello ^[2] ; Christofolini, Denise Maria ^[1] ; Fonseca, Fernando Luiz Affonso ^[3] ; Lagana, Antonio Simone ^[4] ; Barbosa, Caio Parente ^[1] ; Bianco, Bianca ^[1]

Affiliation

^[1] Fac Med ABC, Discipline Sexual & Reprod Hlth & Populat Genet, Dept Collect Hlth, Santo Andre, SP - Brazil

^[2] Fac Med ABC, Program Postgrad Res & Innovat, Santo Andre, SP - Brazil

^[3] Fac Med ABC, Discipline Clin Anal, Dept Patol, Santo Andre, SP - Brazil

^[4] Univ Insubria, Dept Obstet & Gynecol, Filippo Del Ponte Hosp, Varese - Italy

• Document type: Journal article
• Source: Gynecological Endocrinology; v. 37, n. 4 JUL 2020.
• Web of Science Citations: 3

Abstract

Objetive:Several biomarkers of ovarian reserve have been proposed as possible predictors of the response to controlled ovarian stimulation (COS). We aimed to evaluate age, FSH, AMH, antral follicle count (AFC), and ovarian response prediction index (ORPI), as potential predictors of response to COS. Methods:Cross-sectional study enrolling of 188 infertile women who underwent the first cycle of IVF/ICSI. AFC was evaluated; serum FSH and AMH levels were measured by ELISA. ORPI was calculated as AMH x AFC/patient ` s age. Results:As expected, hypo-responder group had less retrieved oocytes, MII, and embryos compared to the good responders. The hyper-response patients were younger, with lower FSH, increased AMH, AFC, and ORPI values. Regarding the assessment of the predictive capacity of ovarian reserve tests, none of them individually or combined showed a good predictive capacity for hypo-response. With respect to the hyper-responder group, individually AMH was the best predictor, while in the multivariable model, ORPI demonstrated the best predictive capacity. Furthermore, patients with serum AMH < 2.09 ng/mL (p25) had fewer AFC than patients with higher AMH values. Conclusions:Our findings suggest that none of the ovarian reserve tests showed a good predictive capacity for hypo-response, while the ORPI was the strongest predictor of hyper-response in normovulatory infertile women. (AU)

• FAPESP's process: 14/06177-2 - Evaluation of mutations/polymorphisms in candidate genes in infertile women and its correlation with human reproduction outcomes
• Grantee: Bianca Alves Vieira Bianco
• Support Opportunities: Regular Research Grants