New insights into two ciprofloxacin-intercalated arrangements for layered double hydroxide carrier materials

Author(s)

Cherif, Nawal Fodil ^{[1, 2, 3]} ; Leopoldo Constantino, Vera Regina ^[4] ; Hamdaoui, Oualid ^[5] ; Leroux, Fabrice ^[1] ; Taviot-Gueho, Christine ^[1]

Affiliation

^[1] Univ Clermont Auvergne, UMR CNRS 6296, Inst Chim Clermont Ferrand, Campus Cezeaux, 24 Ave Landais, BP 800 26, F-63171 Aubiere - France

^[2] Badji Mokhtar Annaba Univ, Lab Environm Engn, POB 12, Annaba 23000 - Algeria

^[3] Ctr Rech Sci & Tech Anal Phys Chim, Zone Ind Bou Ismail, BP 384, Tipasa - Algeria

^[4] Univ Sao Paulo, Inst Quim, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo - Brazil

^[5] King Saud Univ, Chem Engn Dept, Coll Engn, POB 800, Riyadh 11421 - Saudi Arabia

• Document type: Journal article
• Source: NEW JOURNAL OF CHEMISTRY; v. 44, n. 24, p. 10076-10086, JUN 28 2020.
• Web of Science Citations: 0

Abstract

This paper describes the intercalation of ciprofloxacin (CIP), a bactericidal antibiotic, into the interlayer space of layered double hydroxides (LDHs). To counter the problem of bacterial resistance and also to improve the properties of the CIP drug, the drug carrier approach promises significant benefits. Through the tight control over the synthesis parameters, particularly the amounts of CIP with respect to aluminum ions, two different LDH-CIP-intercalated structures were obtained with significantly different interlayer distances, namely, 21 and 32 angstrom. The samples were fully characterized in terms of composition, structure, and morphology. Interestingly, the structure with the largest interlayer distance incorporated both CIP anions and Al(CIP)(3)complex, exhibiting the possibility to increase the CIP drug loading beyond the anionic-exchange capacity of the LDH carrier.In vitrorelease in a simulated intestinal fluid (phosphate-buffered solution at pH 7.5) confirmed that LDH was a potentially efficient carrier to deliver CIP in a sustained mannerviathe anion-exchange mechanism. Different release rates were observed depending on the intercalated structure, which were also influenced by the morphological characteristics. (AU)

• FAPESP's process: 16/50317-9 - Biocompatible nanovectors based on hybrid lamellar materials and composites with polymers for drug release
• Grantee: Vera Regina Leopoldo Constantino
• Support type: Regular Research Grants