Social stress as a trigger for depressive-like behavior and persistent hyperalgesia in mice: study of the comorbidity between depression and chronic pain

Author(s)

Piardi, L. N. ^[1] ; Pagliusi, M. ^[1] ; Bonet, I. J. M. ^[2] ; Brandao, A. F. ^[1] ; Magalhaes, S. F. ^[1] ; Zanelatto, F. B. ^[1] ; Tambeli, C. H. ^[1] ; Parada, C. A. ^[1] ; Sartori, C. R. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Rua Monteiro Lobato, 255, Cidade Univ Zeferino Vaz, BR-13083865 Campinas, SP - Brazil

^[2] Univ Calif San Francisco, Dept Oral & Maxillofacial Surg, 513 Parnassus Ave, Box 0440 S709, San Francisco, CA 94143 - USA

• Document type: Journal article
• Source: Journal of Affective Disorders; v. 274, p. 759-767, SEP 1 2020.
• Web of Science Citations: 0

Abstract

Background: There is great comorbidity and similarity between chronic pain and major depressive disorders. We have recently shown that 10 days of social defeat stress (SDS) induces hyperalgesia regardless depressive-like behavior in mice. Here we aimed to investigate whether social stress predisposes to chronic pain and, inversely, whether chronic pain predisposes to stress-induced depression. Methods: Firstly, we used the 10 days SDS paradigm in mice followed by a mild protocol of repetitive in- flammatory stimulus to evaluate if SDS would predispose to persistent hyperalgesia development. Secondly, we used the intense protocol of repetitive inflammatory stimulus followed by a subthreshold SDS to evaluate if persistent hyperalgesia would predispose to depressive-like behavior of social avoidance. Results: Our results showed that SDS predispose to chronic pain, since stressed mice injected with PGE(2) for 7 days (mild protocol), stimuli normally not sufficient to trigger chronic pain, showed persistent hyperalgesia. Also, we showed that persistent hyperalgesia induced by repetitive inflammatory stimuli predispose to long- lasting depressive-like behavior of social avoidance induced by subthreshold SDS. Limitations: We did not analyze molecular mechanism associated with chronic pain and depressive-like behavior induced by SDS. However, we hypothesized that SDS and 14 days of PGE(2) would generate neuroplasticity on brain areas shared by chronic pain and depression, predisposing to pain chronification and depressive-like be- havior, respectively. Conclusions: We can conclude social stress as a key and a common factor for chronic pain and depression. We can also conclude that SDS predisposes to chronic pain and, inversely, chronic pain predisposes to depressive-like behavior. (AU)

• FAPESP's process: 15/26777-7 - Study of preventive and therapeutic effects of physical exercise on hyperalgesia induced by social defeat stress in mice and associated neuroplastic mechanisms.
• Grantee: Cesar Renato Sartori
• Support Opportunities: Regular Research Grants