Flavivirus Infection Associated with Cerebrovascular Events

Author(s)

Estofolete, Cassia F. ^[1] ; Milhim, Bruno H. G. A. ^[1] ; Zini, Nathalia ^[1] ; Scamardi, Samuel N. ^[1] ; Selvante, Joana D'Arc ^[1] ; Vasilakis, Nikos ^{[2, 3, 4, 5]} ; Nogueira, Mauricio L. ^[1]

Affiliation

^[1] Sao Jose do Rio Preto Med Sch, Dept Infect Dermatol & Parasit Infect, BR-15090000 Sao Jose Do Rio Preto - Brazil

^[2] Univ Texas Med Branch, Dept Pathol, 301 Univ Blvd, Galveston, TX 77555 - USA

^[3] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, 301 Univ Blvd, Galveston, TX 77555 - USA

^[4] Univ Texas Med Branch, Ctr Trop Dis, 301 Univ Blvd, Galveston, TX 77555 - USA

^[5] Univ Texas Med Branch, Inst Human Infect & Immun, 301 Univ Blvd, Galveston, TX 77555 - USA

• Document type: Journal article
• Source: Viruses-Basel; v. 12, n. 6 JUN 2020.
• Web of Science Citations: 0

Abstract

Arthropod-borne viruses (arboviruses) of the genusFlavivirusare distributed globally and cause significant human disease and mortality annually. Flavivirus infections present a spectrum of clinical manifestations, ranging from asymptomatic to severe manifestations, including hemorrhage, encephalitis and death. Herein, we describe 3 case reports of cerebrovascular involvement in patients infected by dengue and Zika viruses in Sao Jose do Rio Preto, Sao Paulo State, Brazil, a hyperendemic area for arbovirus circulation, including dengue, yellow fever, chikungunya and Saint Louis encephalitis viruses. Our findings highlight the potential threat that unusual clinical manifestations may pose to arbovirus disease management and recovery. (AU)

• FAPESP's process: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018
• Grantee: Maurício Lacerda Nogueira
• Support Opportunities: Research Projects - Thematic Grants