| Full text | |
| Author(s): |
Junho, Carolina Victoria Cruz
[1]
;
Caio-Silva, Wellington
[1]
;
Trentin-Sonoda, Mayra
[2]
;
Carneiro-Ramos, Marcela Sorelli
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Fed ABC, Ctr Nat & Human Sci CCNH, Santo Andre, SP - Brazil
[2] Univ Ottawa, Ottawa Hosp, Kidney Res Ctr, Dept Med, Div Nephrol, Res Inst, Ottawa, ON - Canada
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | FRONTIERS IN PHYSIOLOGY; v. 11, JUL 14 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Calcium/calmodulin-dependent protein kinases (CaMKs) are key regulators of calcium signaling in health and disease. CaMKII is the most abundant isoform in the heart; although classically described as a regulator of excitation-contraction coupling, recent studies show that it can also mediate inflammation in cardiovascular diseases (CVDs). Among CVDs, cardiorenal syndrome (CRS) represents a pressing issue to be addressed, considering the growing incidence of kidney diseases worldwide. In this review, we aimed to discuss the role of CaMK as an inflammatory mediator in heart and kidney interaction by conducting an extensive literature review using the database PubMed. Here, we summarize the role and regulating mechanisms of CaMKII present in several quality studies, providing a better understanding for future investigations of CamKII in CVDs. Surprisingly, despite the obvious importance of CaMKII in the heart, very little is known about CaMKII in CRS. In conclusion, more studies are necessary to further understand the role of CaMKII in CRS. (AU) | |
| FAPESP's process: | 08/10175-4 - Impact of inflammatory response induced by acute renal ischemia in cardiac tissue |
| Grantee: | Marcela Sorelli Carneiro Ramos |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/16908-4 - The role of Toll-like receptors 2 and 4 in the development of cardiomyocyte hypertrophy in vitro: participation of NF-kB signaling |
| Grantee: | Juliana Morais Alvim |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |