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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An Overview of the Role of Calcium/Calmodulin-Dependent Protein Kinase in Cardiorenal Syndrome

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Author(s):
Junho, Carolina Victoria Cruz [1] ; Caio-Silva, Wellington [1] ; Trentin-Sonoda, Mayra [2] ; Carneiro-Ramos, Marcela Sorelli [1]
Total Authors: 4
Affiliation:
[1] Univ Fed ABC, Ctr Nat & Human Sci CCNH, Santo Andre, SP - Brazil
[2] Univ Ottawa, Ottawa Hosp, Kidney Res Ctr, Dept Med, Div Nephrol, Res Inst, Ottawa, ON - Canada
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN PHYSIOLOGY; v. 11, JUL 14 2020.
Web of Science Citations: 0
Abstract

Calcium/calmodulin-dependent protein kinases (CaMKs) are key regulators of calcium signaling in health and disease. CaMKII is the most abundant isoform in the heart; although classically described as a regulator of excitation-contraction coupling, recent studies show that it can also mediate inflammation in cardiovascular diseases (CVDs). Among CVDs, cardiorenal syndrome (CRS) represents a pressing issue to be addressed, considering the growing incidence of kidney diseases worldwide. In this review, we aimed to discuss the role of CaMK as an inflammatory mediator in heart and kidney interaction by conducting an extensive literature review using the database PubMed. Here, we summarize the role and regulating mechanisms of CaMKII present in several quality studies, providing a better understanding for future investigations of CamKII in CVDs. Surprisingly, despite the obvious importance of CaMKII in the heart, very little is known about CaMKII in CRS. In conclusion, more studies are necessary to further understand the role of CaMKII in CRS. (AU)

FAPESP's process: 08/10175-4 - Impact of inflammatory response induced by acute renal ischemia in cardiac tissue
Grantee:Marcela Sorelli Carneiro Ramos
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 14/16908-4 - The role of Toll-like receptors 2 and 4 in the development of cardiomyocyte hypertrophy in vitro: participation of NF-kB signaling
Grantee:Juliana Morais Alvim
Support Opportunities: Scholarships in Brazil - Scientific Initiation