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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Early diagnosis and treatment of Alzheimer's disease: new definitions and challenges

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Author(s):
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Pais, Marcos [1] ; Martinez, Luana [1] ; Ribeiro, Octavio [1] ; Loureiro, Julia [1] ; Fernandez, Romel [1] ; Valiengo, Leandro [1] ; Canineu, Paulo [1, 2] ; Stella, Florindo [3, 1] ; Talib, Leda [1] ; Radanovic, Marcia [1] ; Forlenza, V, Orestes
Total Authors: 11
Affiliation:
[1] V, Univ Sao Paulo HCFMUSP, Fac Med, Hosp Clin, Lab Neurociencias LIM27, Dept & Inst Psiquiatria, Sao Paulo, SP - Brazil
[2] Pontificia Univ Catolica Sao Paulo PUC SP, Programa Gerontol, Sao Paulo, SP - Brazil
[3] Univ Estadual Paulista UNESP, Inst Biociencias, Rio Claro, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Revista Brasileira de Psiquiatria; v. 42, n. 4, p. 431-441, JUL-AUG 2020.
Web of Science Citations: 3
Abstract

The prevalence of Alzheimer's disease (AD), a progressive neurodegenerative disorder, is expected to more than double by 2050. Studies on the pathophysiology of AD have been changing our understanding of this disorder and setting a new scenario for drug development and other therapies. Concepts like the ``amyloid cascade{''} and the ``continuum of AD,{''} discussed in this article, are now well established. From updated classifications and recommendations to advances in biomarkers of AD, we aim to critically assess the literature on AD, addressing new definitions and challenges that emerged from recent studies on the subject. Updates on the status of major clinical trials are also given, and future perspectives are discussed. (AU)

FAPESP's process: 14/50873-3 - INCT 2014: National Institute of Biomarkers in Neuropsychiatry
Grantee:Wagner Farid Gattaz
Support type: Research Projects - Thematic Grants