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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zinc Supplementation: Immune Balance of Pregnancy During the Chronic Phase of the Chagas Disease

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Bronzon da Costa, Cassia Mariana [1] ; del Vecchio Filipin, Marina [1] ; Santello, Fabricia Helena [1] ; Gallo, Inara Fernanda Lage [1] ; Pereira, Luiz Miguel [1] ; Barbosa Jr, Fernando ; do Prado Junior, Jose Clovis [2] ; Abrahao, Ana Amelia Carraro [2]
Total Authors: 8
[1] Univ Sao Paulo, Dept Clin Anal Toxicol & Food Sci, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto - Brazil
[2] Barbosa Jr, Jr., Fernando, Univ Sao Paulo, Dept Clin Anal Toxicol & Food Sci, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ACTA PARASITOLOGICA; v. 65, n. 3, p. 599-609, SEP 2020.
Web of Science Citations: 0

Background Chagas disease or American trypanosomiasis is caused by the protozoanTrypanosoma cruziand is endemic of the Americas. The control of the disease is restricted to toxic and potentially teratogenic drugs, which limit the use during pregnancy. The use of food supplementation offers a safe and low-cost form to alleviate Chagas disease symptoms, mostly in areas with alimentary risk. For example, zinc demonstrates positive effects in immune response, including in Chagas disease during pregnancy. Purpose This study describes the innate response in pregnant rats chronically infected withT. cruziand supplemented with zinc. Methods Pregnant female Wistar rats, infected withT. cruzi, were treated with 20 mg/kg/day zinc sulfate and euthanized on the 18th day. Samples (plasma, splenocytes, and peritoneal exudate) were collected and several immune parameters (nitric oxide, RT1B, CD80/CD86, MCP-1, CD11b/c, NK/NKT, IL-2, IL-10, INF-cc, and apoptosis) evaluated. Results Under Zinc supplementation and/orT. cruziinfection, the gestation developed normally. Several innate immune parameters such as RT1B, CD80/CD86, MCP-1 expressing lymphocytes, IL-2, and IL-17 were positively altered, whereas nitric oxide, CD11b/c, NK/NKT, apoptosis, INF-gamma, and corticosterone demonstrated a pro-pregnancy pattern. Conclusion Our results indicated that zinc has diverse effects on immune response during pregnancy. An anti-T. cruziimmunity, as well as a pro-gestation response, were observed after zinc supplementation. The complete comprehension of zinc supplementation in pregnancy will base an adequate strategy to alleviate Chagas disease symptoms and propagation, especially for populations from endemic areas. (AU)

FAPESP's process: 13/04205-6 - Zinc: phenotypic characterization of T lymphocytes, and Treg cells during pregnancy in wistar rats infected with the Y strain Trypanosoma cruzi
Grantee:Cássia Mariana Bronzon da Costa
Support type: Scholarships in Brazil - Doctorate