| Full text | |
| Author(s): |
Mussagy, Cassamo U.
[1, 2]
;
Tabanez, Naiara L.
[2]
;
Farias, Fabiane O.
[3]
;
Kurnia, Kiki A.
[4]
;
Mafra, Marcos R.
[3]
;
Pereira, Jorge F. B.
[2, 5]
Total Authors: 6
|
| Affiliation: | [1] Univ Aveiro, Dept Chem, CICECO Aveiro Inst Mat, P-3810193 Aveiro - Portugal
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Engn Bioproc & Biotechnol, BR-14800903 Araraquara, SP - Brazil
[3] Fed Univ Parana UFPR, Polytech Ctr, Dept Chem Engn, Curitiba, Parana - Brazil
[4] Univ Airlangga, Fac Fisheries & Marine, Dept Marine, Jalan Mulyorejo Kampus C, Surabaya 60115 - Indonesia
[5] Univ Coimbra, CIEPQPF, Dept Chem Engn, Rua Silvio Lima, Polo 2 Pinhal de Marrocos, P-3030790 Coimbra - Portugal
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Chemical Physics Letters; v. 754, SEP 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Ionic liquids (ILs)-based aqueous biphasic systems (ABS) are efficient platforms for the extraction and purification of biomolecules. To find more biocompatible ABS, propylammonium-based ILs, phosphate salts and water were mixed at three temperatures, evaluating the influence of IL and temperature on the liquid-liquid equilibria (LLE). The biphasic region increases with the increase of IL' anionic/cationic chain and decreases with the increase of temperature. There is good agreement between the IL' ability to form ABS and the hydrogen bonding interaction predicted by COSMO-RS. The subtle balance of hydrogen bonding between salt anion-water and IL anion-water governs the phase separation. (AU) | |
| FAPESP's process: | 15/50058-0 - Characterization and modelling of aqueous two-phase systems (ATPS) composed of ionic liquids (ILs) and polymers: a boost towards develiping sustainable biopharmaceutical separion |
| Grantee: | Jorge Pereira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/16424-7 - Optimization and scale-up of liquid-liquid extraction process with ionic liquids (ILs) as a sustainable tool for the separation of the anti-leukemia biopharmaceutical L-asparaginase (ASPase) |
| Grantee: | Jorge Pereira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/19793-3 - Optimization and scale-up of novel Ionic-Liquid-based purification processes for recombinant green fluorescent protein produced by Escherichia coli "GFPurIL" |
| Grantee: | Sandro Roberto Valentini |
| Support Opportunities: | Regular Research Grants |